Recent trends in biocatalysis
Biocatalysis has undergone revolutionary progress in the past century. Benefited by the
integration of multidisciplinary technologies, natural enzymatic reactions are constantly …
integration of multidisciplinary technologies, natural enzymatic reactions are constantly …
Biocatalysis making waves in organic chemistry
Biocatalysis has an enormous impact on chemical synthesis. The waves in which
biocatalysis has developed, and in doing so changed our perception of what organic …
biocatalysis has developed, and in doing so changed our perception of what organic …
The quantum chemical cluster approach in biocatalysis
Conspectus The quantum chemical cluster approach has been used for modeling enzyme
active sites and reaction mechanisms for more than two decades. In this methodology, a …
active sites and reaction mechanisms for more than two decades. In this methodology, a …
Oxidoreductase-catalyzed synthesis of chiral amines
Chiral amines are valuable constituents of many important pharmaceutical compounds and
their intermediates. It is estimated that∼ 40%–45% of small molecule pharmaceuticals …
their intermediates. It is estimated that∼ 40%–45% of small molecule pharmaceuticals …
Broadening the scope of biocatalytic C–C bond formation
Enzymes exercise impeccable control over chemoselectivity, site selectivity and
stereoselectivity in reactions they mediate, such that we have witnessed a surge in the …
stereoselectivity in reactions they mediate, such that we have witnessed a surge in the …
The role of biocatalysis in the asymmetric synthesis of alkaloids–an update
Alkaloids are a group of natural products with interesting pharmacological properties and a
long history of medicinal application. Their complex molecular structures have fascinated …
long history of medicinal application. Their complex molecular structures have fascinated …
Recent advances in biocatalysis of nitrogen-containing heterocycles
Nitrogen-containing heterocycles (N-heterocycles) are ubiquitous in both organisms and
pharmaceutical products. Biocatalysts are providing green approaches for synthesizing …
pharmaceutical products. Biocatalysts are providing green approaches for synthesizing …
Enzymatic Pictet–Spengler reaction: computational study of the mechanism and enantioselectivity of norcoclaurine synthase
The Pictet–Spengler (PS) reaction, ie, the acid-catalyzed condensation between β-
arylethylamine and an aldehyde or a ketone and the subsequent ring closure, is an …
arylethylamine and an aldehyde or a ketone and the subsequent ring closure, is an …
Asymmetric Synthesis of Fused-Ring Tetrahydroisoquinolines and Tetrahydro-β-carbolines from 2-Arylethylamines via a Chemoenzymatic Approach
L Yang, J Li, Z Xu, P Yao, Q Wu, D Zhu, Y Ma - Organic Letters, 2022 - ACS Publications
While chiral fused-ring tetrahydroisoquinoline (THIQ) and tetrahydro-β-carboline (THβC)
scaffolds have attracted considerable interest due to their wide spectrum of biological …
scaffolds have attracted considerable interest due to their wide spectrum of biological …
Deracemization of Racemic Amines to Enantiopure (R)‐ and (S)‐amines by Biocatalytic Cascade Employing ω‐Transaminase and Amine Dehydrogenase
A one‐pot deracemization strategy for α‐chiral amines is reported involving an
enantioselective deamination to the corresponding ketone followed by a stereoselective …
enantioselective deamination to the corresponding ketone followed by a stereoselective …