As our understanding of the cell interior has grown, we have come to appreciate that most
cellular operations are localized, that is, they occur at discrete and identifiable locations or …

Conspectus Proximity labeling can be defined as an enzymatic “in-cell” chemical reaction
that catalyzes the proximity-dependent modification of biomolecules in live cells. Since the …

Although the subcellular dynamics of RNA and proteins are key determinants of cell
homeostasis, their characterization is still challenging. Here we present an integrative …

RNA localization is highly regulated, with subcellular organization driving context-
dependent cell physiology. Although proximity-based labelling technologies that use highly …

Spatial regulation of RNA plays a critical role in gene expression regulation and cellular
function. Understanding spatially resolved RNA dynamics and translation is vital for bringing …

The term “undruggable” refers to proteins or other biological targets that have been
historically challenging to target with conventional drugs or therapeutic strategies because …

At its most fundamental level, life is a collection of synchronized cellular processes driven by
interactions among biomolecules. Proximity labeling has emerged as a powerful technique …

Alternative polyadenylation (APA) is a widespread and conserved regulatory mechanism
that generates diverse 3′ ends on mRNA. APA patterns are often tissue specific and play …

RNA secondary structure plays essential roles in encoding RNA regulatory fate and function.
Most RNAs populate ensembles of alternatively paired states and are continually unfolded …

The proximitome is defined as the entire collection of biomolecules spatially in the proximity
of a biomolecule of interest. More broadly, the concept of the proximitome can be extended …