Zinc (II) ions are redox-inert in biology. Yet, their interaction with sulfur of cysteine in cellular
proteins can confer ligand-centered redox activity on zinc coordination sites, control protein …

Protein design is a valuable tool for understanding the fundamental factors that dictate
protein structure and function. The field of protein design has seen significant progress over …

This review provides a comprehensive overview of the functional roles of disulfide bonds
and their relevance to human disease. The critical roles of disulfide bonds in protein …

It has been known for many decades that cell surface, soluble-secreted, and extracellular
matrix proteins are generally rich in disulfide bonds, but only more recently has the …

Protein oxidation sits at the intersection of multiple signalling pathways, yet the magnitude
and extent of crosstalk between oxidation and other post-translational modifications remains …

We developed a high-throughput mass spectrometry method, pLink-SS (http://pfind. ict. ac.
cn/software/pLink/2014/pLink-SS. html), for precise identification of disulfide-linked peptides …

Metalloproteomics includes approaches that address the expression of metalloproteins and
their changes in biological time and space. Metalloproteomes are investigated by a …

Electrochemistry studies charge transfer and related processes at various microscopic
structures (atomic steps, islands, pits and kinks on electrodes), and mesoscopic materials …

Protein action in nature is largely controlled by the level of expression and by post-
translational modifications. Post-translational modifications result in a proteome that is at …

Significance: Cellular redox processes are highly interconnected, yet not in equilibrium, and
governed by a wide range of biochemical parameters. Technological advances continue …