Balanced general anesthesia, the most common management strategy used in anesthesia
care, entails the administration of different drugs together to create the anesthetic state …

The widely used electroencephalogram-based indices for depth-of-anesthesia monitoring
assume that the same index value defines the same level of unconsciousness for all …

We propose an integrated and adaptable approach to improve patient care and clinical
outcomes through analgesia and light sedation, initiated early during an episode of critical …

General anesthesia is characterized by loss of consciousness, amnesia, analgesia, and
immobility. Important molecular targets of general anesthetics have been identified, but the …

Background Anaesthetic drugs act at sites within the brain that undergo profound changes
during typical ageing. We postulated that anaesthesia-induced brain dynamics observed in …

Despite lack of paediatric labelling, contributions to the literature on paediatric applications
of dexmedetomidine have increased over recent years. Dexmedetomidine possesses many …

Reliable electroencephalography (EEG) signatures of transitions between consciousness
and unconsciousness under anaesthesia have not yet been identified. Herein we examined …

Background Postoperative delirium is associated with an increased risk of morbidity and
mortality, especially in the elderly. Delirium in the postanaesthesia care unit (PACU) could …

Background The delirium-sparing effect of nighttime dexmedetomidine has not been studied
after surgery. We hypothesised that a nighttime dose of dexmedetomidine would reduce the …

The brain is one of the most metabolically active organs in the body. The brain's high energy
demand associated with wakefulness persists during rapid eye movement sleep, and even …