Signaling pathways and targeted therapy for myocardial infarction

Q Zhang, L Wang, S Wang, H Cheng, L Xu… - Signal transduction and …, 2022 - nature.com
Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …

Extracellular vesicles in cardiovascular disease: biological functions and therapeutic implications

C Han, J Yang, J Sun, G Qin - Pharmacology & therapeutics, 2022 - Elsevier
Extracellular vesicles (EVs), including exosomes and microvesicles, are lipid bilayer
particles naturally released from the cell. While exosomes are formed as intraluminal …

[HTML][HTML] Current challenges surrounding exosome treatments

E Tzng, N Bayardo, PC Yang - Extracellular Vesicle, 2023 - Elsevier
Cardiovascular disease is the leading cause of death worldwide today and numerous
studies are demonstrating that exosomes improve cardiac function after myocardial injury …

Extracellular vesicles: emerging roles, biomarkers and therapeutic strategies in fibrotic diseases

J Zhu, S Wang, D Yang, W Xu, H Qian - Journal of Nanobiotechnology, 2023 - Springer
Extracellular vesicles (EVs), a cluster of cell-secreted lipid bilayer nanoscale particles,
universally exist in body fluids, as well as cell and tissue culture supernatants. Over the past …

Stem cell-derived extracellular vesicles as new tools in regenerative medicine-immunomodulatory role and future perspectives

E Karnas, P Dudek, EK Zuba-Surma - Frontiers in immunology, 2023 - frontiersin.org
In the last few decades, the practical use of stem cells (SCs) in the clinic has attracted
significant attention in the regenerative medicine due to the ability of these cells to proliferate …

Plant-RNA in extracellular vesicles: the secret of cross-kingdom communication

O Urzì, R Gasparro, NR Ganji, R Alessandro… - Membranes, 2022 - mdpi.com
The release of extracellular vesicles (EVs) is a common language, used by living organisms
from different kingdoms as a means of communication between them. Extracellular vesicles …

Extracellular vesicles mediate biological information delivery: A double-edged sword in cardiac remodeling after myocardial infarction

P Cheng, X Wang, Q Liu, T Yang, H Qu… - Frontiers in …, 2023 - frontiersin.org
Acute myocardial infarction (AMI) is a severe ischemic disease with high morbidity and
mortality worldwide. Maladaptive cardiac remodeling is a series of abnormalities in cardiac …

miRNAs epigenetic tuning of wall remodeling in the early phase after myocardial infarction: A Novel epidrug approach

F Salvatori, E D'Aversa, ML Serino, AV Singh… - International Journal of …, 2023 - mdpi.com
Myocardial infarction (MI) is one of the leading causes of death in Western countries. An
early diagnosis decreases subsequent severe complications such as wall remodeling or …

Bioactivity and miRNome profiling of native extracellular vesicles in human induced pluripotent stem cell‐cardiomyocyte differentiation

AF Louro, MA Paiva, MR Oliveira, KA Kasper… - Advanced …, 2022 - Wiley Online Library
Extracellular vesicles (EV) are an attractive therapy to boost cardiac regeneration.
Nevertheless, identification of native EV and corresponding cell platform (s) suitable for …

Extracellular vesicle‐packaged mitochondrial disturbing miRNA exacerbates cardiac injury during acute myocardial infarction

P Sun, C Wang, G Mang, X Xu, S Fu… - Clinical and …, 2022 - Wiley Online Library
Mounting evidence suggests that extracellular vesicles (EVs) are effective communicators in
biological signalling in cardiac physiology and pathology. However, the role of EVs in …