Targeting FTO suppresses cancer stem cell maintenance and immune evasion

The roles and implications of RNA m6A modification in cancer

X Deng, Y Qing, D Horne, H Huang… - Nature Reviews Clinical …, 2023 - nature.com
Abstract N 6-Methyladenosine (m6A), the most prevalent internal modification in eukaryotic
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
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The role of m6A RNA methylation in cancer metabolism

Y An, H Duan - Molecular cancer, 2022 - Springer
Metabolic reprogramming is one of the main characteristics of malignant tumors, which is
due to the flexible changes of cell metabolism that can meet the needs of cell growth and …
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[HTML][HTML] Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells

J ** the tumor
microenvironment (TME), the mechanisms by which TAMs influence the TME and contribute …
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The hallmarks of cancer immune evasion

C Galassi, TA Chan, I Vitale, L Galluzzi - Cancer Cell, 2024 - cell.com
According to the widely accepted" three Es" model, the host immune system eliminates
malignant cell precursors and contains microscopic neoplasms in a dynamic equilibrium …
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METTL16 exerts an m6A-independent function to facilitate translation and tumorigenesis

R Su, L Dong, Y Li, M Gao, PC He, W Liu, J Wei… - Nature cell …, 2022 - nature.com
METTL16 has recently been identified as an RNA methyltransferase responsible for the
deposition of N 6-methyladenosine (m6A) in a few transcripts. Whether METTL16 methylates …
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