Genetics of the human Y chromosome and its association with male infertility
The human Y chromosome harbors genes that are responsible for testis development and
also for initiation and maintenance of spermatogenesis in adulthood. The long arm of the Y …
also for initiation and maintenance of spermatogenesis in adulthood. The long arm of the Y …
Y-chromosome evolution: emerging insights into processes of Y-chromosome degeneration
The human Y chromosome is intriguing not only because it harbours the master-switch gene
that determines gender but also because of its unusual evolutionary history. The Y …
that determines gender but also because of its unusual evolutionary history. The Y …
GENESPACE tracks regions of interest and gene copy number variation across multiple genomes
The development of multiple chromosome-scale reference genome sequences in many
taxonomic groups has yielded a high-resolution view of the patterns and processes of …
taxonomic groups has yielded a high-resolution view of the patterns and processes of …
COVID-19 and individual genetic susceptibility/receptivity: role of ACE1/ACE2 genes, immunity, inflammation and coagulation. Might the double X-chromosome in …
In December 2019, a novel severe acute respiratory syndrome (SARS) from a new
coronavirus (SARS-CoV-2) was recognized in the city of Wuhan, China. Rapidly, it became …
coronavirus (SARS-CoV-2) was recognized in the city of Wuhan, China. Rapidly, it became …
[HTML][HTML] Telomere-to-telomere assembly of a complete human X chromosome
After two decades of improvements, the current human reference genome (GRCh38) is the
most accurate and complete vertebrate genome ever produced. However, no single …
most accurate and complete vertebrate genome ever produced. However, no single …
Landscape of X chromosome inactivation across human tissues
X chromosome inactivation (XCI) silences transcription from one of the two X chromosomes
in female mammalian cells to balance expression dosage between XX females and XY …
in female mammalian cells to balance expression dosage between XX females and XY …
Recombination between heterologous human acrocentric chromosomes
The short arms of the human acrocentric chromosomes 13, 14, 15, 21 and 22 (SAACs) share
large homologous regions, including ribosomal DNA repeats and extended segmental …
large homologous regions, including ribosomal DNA repeats and extended segmental …
Ancient admixture in human history
Population mixture is an important process in biology. We present a suite of methods for
learning about population mixtures, implemented in a software package called …
learning about population mixtures, implemented in a software package called …
The complete sequence and comparative analysis of ape sex chromosomes
Apes possess two sex chromosomes—the male-specific Y chromosome and the X
chromosome, which is present in both males and females. The Y chromosome is crucial for …
chromosome, which is present in both males and females. The Y chromosome is crucial for …
Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators
The human X and Y chromosomes evolved from an ordinary pair of autosomes, but millions
of years ago genetic decay ravaged the Y chromosome, and only three per cent of its …
of years ago genetic decay ravaged the Y chromosome, and only three per cent of its …