How is pluripotency determined and maintained?
H Niwa - 2007 - journals.biologists.com
Mouse embryonic stem (ES) cells are pluripotent, as they have the ability to differentiate into
the various cell types of a vertebrate embryo. Pluripotency is a property of the inner cell …
the various cell types of a vertebrate embryo. Pluripotency is a property of the inner cell …
MicroRNAs (miRNAs) in neurodegenerative diseases
Aging‐related neurodegenerative diseases (NDs) are the culmination of many different
genetic and environmental influences. Prior studies have shown that RNAs are …
genetic and environmental influences. Prior studies have shown that RNAs are …
Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells
The pluripotency of embryonic stem (ES) cells is thought to be maintained by a few key
transcription factors, including Oct3/4 and Sox2. The function of Oct3/4 in ES cells has been …
transcription factors, including Oct3/4 and Sox2. The function of Oct3/4 in ES cells has been …
Non-coding RNA: what is functional and what is junk?
AF Palazzo, ES Lee - Frontiers in genetics, 2015 - frontiersin.org
The genomes of large multicellular eukaryotes are mostly comprised of non-protein coding
DNA. Although there has been much agreement that a small fraction of these genomes has …
DNA. Although there has been much agreement that a small fraction of these genomes has …
[HTML][HTML] Genome-wide quantification of RNA flow across subcellular compartments reveals determinants of the mammalian transcript life cycle
Dissecting the regulatory mechanisms controlling mammalian transcripts from production to
degradation requires quantitative measurements of mRNA flow across the cell. We …
degradation requires quantitative measurements of mRNA flow across the cell. We …
Database for mRNA half-life of 19 977 genes obtained by DNA microarray analysis of pluripotent and differentiating mouse embryonic stem cells
LV Sharova, AA Sharov, T Nedorezov, Y Piao… - DNA …, 2009 - academic.oup.com
Degradation of mRNA is one of the key processes that control the steady-state level of gene
expression. However, the rate of mRNA decay for the majority of genes is not known. We …
expression. However, the rate of mRNA decay for the majority of genes is not known. We …
Targeted RNA sequencing reveals the deep complexity of the human transcriptome
Transcriptomic analyses have revealed an unexpected complexity to the human
transcriptome, whose breadth and depth exceeds current RNA sequencing capability …
transcriptome, whose breadth and depth exceeds current RNA sequencing capability …
Transcription factor profiling in individual hematopoietic progenitors by digital RT-PCR
We report here a systematic, quantitative population analysis of transcription factor
expression within developmental progenitors, made possible by a microfluidic chip-based …
expression within developmental progenitors, made possible by a microfluidic chip-based …
The Transcriptome of the Human Pathogen Trypanosoma brucei at Single-Nucleotide Resolution
NG Kolev, JB Franklin, S Carmi, H Shi… - PLoS …, 2010 - journals.plos.org
The genome of Trypanosoma brucei, the causative agent of African trypanosomiasis, was
published five years ago, yet identification of all genes and their transcripts remains to be …
published five years ago, yet identification of all genes and their transcripts remains to be …
Biogenesis and function of circular RNAs in health and in disease
G Haddad, JM Lorenzen - Frontiers in pharmacology, 2019 - frontiersin.org
Circular RNAs (circRNAs) are a class of non-coding RNA that were previously thought to be
insignificant byproducts of splicing errors. However, recent advances in RNA sequencing …
insignificant byproducts of splicing errors. However, recent advances in RNA sequencing …