Isocitrate dehydrogenase (IDH) enzymes catalyse the oxidative decarboxylation of isocitrate
and therefore play key roles in the Krebs cycle and cellular homoeostasis. Major advances …

An abundant supply of amino acids is important for cancers to sustain their proliferative
drive. Alongside their direct role as substrates for protein synthesis, they can have roles in …

2-Hydroxyglutarate (2-HG) is structurally similar to α-ketoglutarate (α-KG), which is an
intermediate product of the tricarboxylic acid (TCA) cycle; it can be generated by reducing …

Oxidative phosphorylation (OXPHOS) defects caused by somatic mitochondrial DNA
mutations increase with age in human colorectal epithelium and are prevalent in colorectal …

Mutations in IDH induce epigenetic and transcriptional reprogramming, differentiation bias,
and susceptibility to mitochondrial inhibitors in cancer cells. Here, we first show that cell …

The metabolism of the non-essential amino acid L-proline is emerging as a key pathway in
the metabolic rewiring that sustains cancer cells proliferation, survival and metastatic …

Previous studies have revealed a role for proline metabolism in supporting cancer
development and metastasis. In this study, we show that many cancer cells respond to loss …

Background Late in the nineteenth century, it was theorized that a circulating product
produced by the parathyroid glands could negatively impact skeletal homeostasis. A century …

Statins are widely prescribed inhibitors of the mevalonate pathway, acting to lower systemic
cholesterol levels. The mevalonate pathway is critical for tumorigenesis and is frequently …

Interest in how proline contributes to cancer biology is expanding because of the emerging
role of a novel proline metabolic cycle in cancer cell survival, proliferation, and metastasis …