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Mechanosensing dysregulation in the fibroblast: a hallmark of the aging heart
The myofibroblast is a specialized fibroblast that expresses α-smooth muscle actin (α-SMA)
and participates in wound contraction and fibrosis. The fibroblast to myofibroblast transition …
and participates in wound contraction and fibrosis. The fibroblast to myofibroblast transition …
Microphysiological systems for human aging research
Recent advances in microphysiological systems (MPS), also known as organs‐on‐a‐chip
(OoC), enable the recapitulation of more complex organ and tissue functions on a smaller …
(OoC), enable the recapitulation of more complex organ and tissue functions on a smaller …
Cell migration orchestrates migrasome formation by sha** retraction fibers
C Fan, X Shi, K Zhao, L Wang, K Shi, YJ Liu, H Li… - Journal of Cell …, 2022 - rupress.org
Migrasomes are recently discovered vesicle-like structures on retraction fibers of migrating
cells that have been linked with transfer of cellular contents, shedding of unwanted …
cells that have been linked with transfer of cellular contents, shedding of unwanted …
3D Bioprinting of Multicellular Stem Cell‐Derived Constructs to Model Pancreatic Cell Differentiation
In vitro models of the pancreas can aid in develo** therapies for pancreatic diseases.
Nonetheless, most pancreatic tissue engineering is limited to insulin‐secreting β‐cells or …
Nonetheless, most pancreatic tissue engineering is limited to insulin‐secreting β‐cells or …
The cellular mechanobiology of aging: from biology to mechanics
Aging is a chronic, complicated process that leads to degenerative physical and biological
changes in living organisms. Aging is associated with permanent, gradual physiological …
changes in living organisms. Aging is associated with permanent, gradual physiological …
Nanoparticle platforms for dermal antiaging technologies: Insights in cellular and molecular mechanisms
Aging is a continuous process defined by a progressive functional decline in physiological
parameters. Skin, being one of the most vulnerable organs, shows early signs of aging …
parameters. Skin, being one of the most vulnerable organs, shows early signs of aging …
Physics and physiology of cell spreading in two and three dimensions
Cells spread on surfaces and within three-dimensional (3-D) matrixes as they grow, divide,
and move. Both chemical and physical signals orchestrate spreading during normal …
and move. Both chemical and physical signals orchestrate spreading during normal …
Electric currents of 448 kHz upregulate anti‐senescence pathways in human dermal fibroblasts
E Toledano‐Macías… - Journal of Cosmetic …, 2024 - Wiley Online Library
Background Currently, finding new therapeutic strategies that reduce skin aging is a
challenge for dermatologists and aesthetic doctors. In recent years, physical therapies have …
challenge for dermatologists and aesthetic doctors. In recent years, physical therapies have …
Multicellular quadruple colorectal cancer spheroids as an in vitro tool for antiangiogenic potential evaluation of nanoparticles
S Carvalho, MJ Silveira, M Domingues… - Advanced …, 2023 - Wiley Online Library
The encapsulation of bevacizumab (BVZ), angiogenesis inhibitor antibody, into nanocarriers
is explored aiming at enhancing its efficacy in colorectal cancer (CRC) treatment while …
is explored aiming at enhancing its efficacy in colorectal cancer (CRC) treatment while …
4-Hydroxynonenal contributes to fibroblast senescence in skin photoaging evoked by UV-A radiation
A Swiader, C Camaré, P Guerby, R Salvayre… - Antioxidants, 2021 - mdpi.com
Solar ultraviolet A (UV-A) radiation promotes a huge variety of damages on connective
tissues and dermal fibroblasts, including cellular senescence, a major contributor of skin …
tissues and dermal fibroblasts, including cellular senescence, a major contributor of skin …