Mechanosensing dysregulation in the fibroblast: a hallmark of the aging heart

A Angelini, JA Trial, J Ortiz-Urbina, KA Cieslik - Ageing research reviews, 2020 - Elsevier
The myofibroblast is a specialized fibroblast that expresses α-smooth muscle actin (α-SMA)
and participates in wound contraction and fibrosis. The fibroblast to myofibroblast transition …

Microphysiological systems for human aging research

S Park, TC Laskow, J Chen, P Guha, B Dawn… - Aging …, 2024 - Wiley Online Library
Recent advances in microphysiological systems (MPS), also known as organs‐on‐a‐chip
(OoC), enable the recapitulation of more complex organ and tissue functions on a smaller …

Cell migration orchestrates migrasome formation by sha** retraction fibers

C Fan, X Shi, K Zhao, L Wang, K Shi, YJ Liu, H Li… - Journal of Cell …, 2022 - rupress.org
Migrasomes are recently discovered vesicle-like structures on retraction fibers of migrating
cells that have been linked with transfer of cellular contents, shedding of unwanted …

3D Bioprinting of Multicellular Stem Cell‐Derived Constructs to Model Pancreatic Cell Differentiation

S Edri, A Newman Frisch, D Safina… - Advanced Functional …, 2024 - Wiley Online Library
In vitro models of the pancreas can aid in develo** therapies for pancreatic diseases.
Nonetheless, most pancreatic tissue engineering is limited to insulin‐secreting β‐cells or …

The cellular mechanobiology of aging: from biology to mechanics

A Bajpai, R Li, W Chen - Annals of the New York Academy of …, 2021 - Wiley Online Library
Aging is a chronic, complicated process that leads to degenerative physical and biological
changes in living organisms. Aging is associated with permanent, gradual physiological …

Nanoparticle platforms for dermal antiaging technologies: Insights in cellular and molecular mechanisms

E Bhatia, D Kumari, S Sharma… - Wiley …, 2022 - Wiley Online Library
Aging is a continuous process defined by a progressive functional decline in physiological
parameters. Skin, being one of the most vulnerable organs, shows early signs of aging …

Physics and physiology of cell spreading in two and three dimensions

PA Janmey, B Hinz, CA McCulloch - Physiology, 2021 - journals.physiology.org
Cells spread on surfaces and within three-dimensional (3-D) matrixes as they grow, divide,
and move. Both chemical and physical signals orchestrate spreading during normal …

Electric currents of 448 kHz upregulate anti‐senescence pathways in human dermal fibroblasts

E Toledano‐Macías… - Journal of Cosmetic …, 2024 - Wiley Online Library
Background Currently, finding new therapeutic strategies that reduce skin aging is a
challenge for dermatologists and aesthetic doctors. In recent years, physical therapies have …

Multicellular quadruple colorectal cancer spheroids as an in vitro tool for antiangiogenic potential evaluation of nanoparticles

S Carvalho, MJ Silveira, M Domingues… - Advanced …, 2023 - Wiley Online Library
The encapsulation of bevacizumab (BVZ), angiogenesis inhibitor antibody, into nanocarriers
is explored aiming at enhancing its efficacy in colorectal cancer (CRC) treatment while …

4-Hydroxynonenal contributes to fibroblast senescence in skin photoaging evoked by UV-A radiation

A Swiader, C Camaré, P Guerby, R Salvayre… - Antioxidants, 2021 - mdpi.com
Solar ultraviolet A (UV-A) radiation promotes a huge variety of damages on connective
tissues and dermal fibroblasts, including cellular senescence, a major contributor of skin …