Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development
Stress proteins (SPs) including heat-shock proteins (HSPs), RNA chaperones, and ER
associated stress proteins are molecular chaperones essential for cellular homeostasis. The …
associated stress proteins are molecular chaperones essential for cellular homeostasis. The …
Insights into structural and mechanistic features of viral IRES elements
Internal ribosome entry site (IRES) elements are cis-acting RNA regions that promote
internal initiation of protein synthesis using cap-independent mechanisms. However, distinct …
internal initiation of protein synthesis using cap-independent mechanisms. However, distinct …
IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex
Abstract Enterovirus 71 (EV71) poses serious threats to human health, particularly in
Southeast Asia, and no drugs or vaccines are available. Previous work identified the stem …
Southeast Asia, and no drugs or vaccines are available. Previous work identified the stem …
Role of MAPK/MNK1 signaling in virus replication
Viruses are obligate intracellular parasites; they heavily depend on the host cell machinery
to effectively replicate and produce new progeny virus particles. Following viral infection …
to effectively replicate and produce new progeny virus particles. Following viral infection …
RNA–small-molecule interaction: challenging the “undruggable” tag
RNA targeting, specifically with small molecules, is a relatively new and rapidly emerging
avenue with the promise to expand the target space in the drug discovery field. From being …
avenue with the promise to expand the target space in the drug discovery field. From being …
Ribosomal control in RNA virus-infected cells
Viruses are strictly intracellular parasites requiring host cellular functions to complete their
reproduction cycle involving virus infection of host cell, viral genome replication, viral protein …
reproduction cycle involving virus infection of host cell, viral genome replication, viral protein …
[HTML][HTML] Advances in anti-EV-A71 drug development research
Abstract Background Enterovirus A71 (EV-A71) is capable of causing hand, foot and mouth
disease (HFMD), which may lead to neurological sequelae and even death. As EV-A71 is …
disease (HFMD), which may lead to neurological sequelae and even death. As EV-A71 is …
Advances and breakthroughs in IRES-directed translation and replication of picornaviruses
SW Abdullah, J Wu, X Wang, H Guo, S Sun - MBio, 2023 - journals.asm.org
Viruses lack the properties to replicate independently due to the limited resources encoded
in their genome; therefore, they hijack the host cell machinery to replicate and survive …
in their genome; therefore, they hijack the host cell machinery to replicate and survive …
Phase separation of heterogeneous nuclear ribonucleoprotein A1 upon specific RNA‐binding observed by magnetic resonance
Interaction of heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) with specific single‐
stranded RNA and its relation to liquid‐liquid phase separation (LLPS) were studied in vitro …
stranded RNA and its relation to liquid‐liquid phase separation (LLPS) were studied in vitro …
Small molecule–RNA targeting: starting with the fundamentals
The structural and regulatory elements in therapeutically relevant RNAs offer many
opportunities for targeting by small molecules, yet fundamental understanding of what drives …
opportunities for targeting by small molecules, yet fundamental understanding of what drives …