The matrix in cancer
TR Cox - Nature Reviews Cancer, 2021 - nature.com
The extracellular matrix is a fundamental, core component of all tissues and organs, and is
essential for the existence of multicellular organisms. From the earliest stages of organism …
essential for the existence of multicellular organisms. From the earliest stages of organism …
Tumor immunotherapies by immune checkpoint inhibitors (ICIs); the pros and cons
The main breakthrough in tumor immunotherapy was the discovery of immune checkpoint
(IC) proteins, which act as a potent suppressor of the immune system by a myriad of …
(IC) proteins, which act as a potent suppressor of the immune system by a myriad of …
The current treatment paradigm for pancreatic ductal adenocarcinoma and barriers to therapeutic efficacy
Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis, with a median survival
time of 10-12 months. Clinically, these poor outcomes are attributed to several factors …
time of 10-12 months. Clinically, these poor outcomes are attributed to several factors …
Context-specific determinants of the immunosuppressive tumor microenvironment in pancreatic cancer
Immunotherapies have shown benefits across a range of human cancers, but not pancreatic
ductal adenocarcinoma (PDAC). Recent evidence suggests that the immunosuppressive …
ductal adenocarcinoma (PDAC). Recent evidence suggests that the immunosuppressive …
The extracellular matrix: its composition, function, remodeling, and role in tumorigenesis
The extracellular matrix (ECM) is a ubiquitous member of the body and is key to the
maintenance of tissue and organ integrity. Initially thought to be a bystander in many cellular …
maintenance of tissue and organ integrity. Initially thought to be a bystander in many cellular …
Tumor-homing and immune-reprogramming cellular nanovesicles for photoacoustic imaging-guided phototriggered precise chemoimmunotherapy
Many studies have focused on develo** effective therapeutic strategies to selectively
destroy primary tumors, eliminate metastatic lesions, and prevent tumor recurrence with …
destroy primary tumors, eliminate metastatic lesions, and prevent tumor recurrence with …
The importance of 3D fibre architecture in cancer and implications for biomaterial model design
JC Ashworth, TR Cox - Nature Reviews Cancer, 2024 - nature.com
The need for improved prediction of clinical response is driving the development of cancer
models with enhanced physiological relevance. A new concept of 'precision biomaterials' is …
models with enhanced physiological relevance. A new concept of 'precision biomaterials' is …
METTL16 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers.
Characterization of genetic alterations will improve our understanding and therapies for this …
Characterization of genetic alterations will improve our understanding and therapies for this …
Immunosuppression, immune escape, and immunotherapy in pancreatic cancer: focused on the tumor microenvironment
YH Zhu, JH Zheng, QY Jia, ZH Duan, HF Yao, J Yang… - Cellular Oncology, 2023 - Springer
Pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, is
characterized by poor treatment response and low survival time. The current clinical …
characterized by poor treatment response and low survival time. The current clinical …
Multifunctional lipid bilayer nanocarriers for cancer immunotherapy in heterogeneous tumor microenvironments, combining immunogenic cell death stimuli with …
In addition to the contribution of cancer cells, the solid tumor microenvironment (TME) has a
critical role in determining tumor expansion, antitumor immunity, and the response to …
critical role in determining tumor expansion, antitumor immunity, and the response to …