Habit modification in pharmaceutical crystallization: A review

S Pu, K Hadinoto - Chemical Engineering Research and Design, 2024 - Elsevier
Besides size and purity, habit represents a critical quality attribute of pharmaceutical
crystals, influencing efficiencies of downstream processing steps and final drug product's …

Continuous crystallization and its potential use in drug substance Manufacture: A review

A Eren, F Civati, W Ma, JC Gamekkanda… - Journal of Crystal …, 2023 - Elsevier
Interest in the continuous manufacturing in the pharmaceutical industry for the production of
Active Pharmaceutical Ingredients (API's) has greatly increased in recent years. This has led …

Recent progress in continuous crystallization of pharmaceutical products: precise preparation and control

Y Ma, S Wu, EGJ Macaringue, T Zhang… - … Process Research & …, 2020 - ACS Publications
Crystallization, as a solid–liquid separation process, is employed to purify and isolate a
great diversity of crystalline pharmaceutical products. In recent years, continuous …

Membrane-cooling coupled crystallization with zero solvent discharge for spherical HMX: Process design, growth kinetics and mechanism

T Wang, Y Wang, S Hao, S Zhang, R Gou, H Li… - Chemical Engineering …, 2023 - Elsevier
The simultaneous achievement of crystal characteristics control and environmentally benign
is challenging the formulation processing of energetic materials (EMs). Herein, a membrane …

Enabling precision manufacturing of active pharmaceutical ingredients: workflow for seeded cooling continuous crystallisations

CJ Brown, T McGlone, S Yerdelen… - … Systems Design & …, 2018 - pubs.rsc.org
Continuous manufacturing is widely used for the production of commodity products.
Currently, it is attracting increasing interest from the pharmaceutical industry and regulatory …

Monitoring polymer flocculation in oil sands tailings: A population balance model approach

V Vajihinejad, JBP Soares - Chemical Engineering Journal, 2018 - Elsevier
Oil sands mature fine tailings are stable suspensions of clay particles and residual bitumen
in an alkaline aqueous medium. They are formed when bitumen is extracted from oil sands …

Insights into membrane crystallization: A sustainable tool for value added product recovery from effluent streams

P Das, S Dutta, KK Singh - Separation and Purification Technology, 2021 - Elsevier
Worldwide waste valorization and recovery of non-utilized components/unreacted
compounds/side streams/byproducts are being researched upon. These are indispensable …

Crystal growth kinetics of an industrial active pharmaceutical ingredient: Implications of different representations of supersaturation and simultaneous growth …

GL Quilló, S Bhonsale, B Gielen… - Crystal Growth & …, 2021 - ACS Publications
The crystal growth kinetics of a proprietary active pharmaceutical ingredient (API) was
investigated by isothermal seeded batch de-supersaturation experiments in solvent mixtures …

Modeling of nucleation, growth, and dissolution of paracetamol in ethanol solution for unseeded batch cooling crystallization with temperature-cycling strategy

Y Kim, Y Kawajiri, RW Rousseau… - Industrial & Engineering …, 2023 - ACS Publications
Controlling crystal size distributions is critical to ensure the quality of products and
operational efficiency for downstream processing. In batch cooling crystallization …

Finite volume approach for fragmentation equation and its mathematical analysis

M Singh, G Walker - Numerical Algorithms, 2022 - Springer
This work is focused on develo** a finite volume scheme for approximating a
fragmentation equation. The mathematical analysis is discussed in detail by examining …