For over three decades, a mainstay and goal of clinical oncology has been the development
of therapies promoting the effective elimination of cancer cells by apoptosis. This …

Acquired resistance to cell death is a hallmark of cancer. The BCL-2 protein family members
play important roles in controlling apoptotic cell death. Abnormal over-expression of pro …

Abstract Background N6-methyladenosine (m6A) modification is the most pervasive
modification in mRNA, and has been considered as a new layer of epigenetic regulation on …

FOXO proteins are transcription factors that are involved in numerous physiological
processes and in various pathological conditions, including cardiovascular disease, cancer …

Phosphatase and Tensin Homolog deleted on Chromosome 10 (PTEN) is a dual
phosphatase with both protein and lipid phosphatase activities. PTEN was first discovered …

In recent years, the study of oxidative stress (OS) has become increasingly popular. In
particular, the role of OS on female fertility is very important and has been focused on …

In multicellular organisms, cell death is a critical and active process that maintains tissue
homeostasis and eliminates potentially harmful cells. There are three major types of …

Recently researchers proposed the term 'Type-3-Diabetes' for Alzheimer's disease (ad)
because of the shared molecular and cellular features among Type-1-Diabetes, Type-2 …

Fucoidan is a natural derived compound found in different species of brown algae and in
some animals, that has gained attention for its anticancer properties. However, the exact …

Abstract Sirtuin 2 (SIRT2) is an NAD+-dependent deacetylase that was under studied
compared to other sirtuin family members. SIRT2 is the only sirtuin protein which is …