Oxidative stress in cardiovascular diseases: still a therapeutic target?
T Senoner, W Dichtl - Nutrients, 2019 - mdpi.com
Cardiovascular diseases (CVD) are complex entities with heterogenous pathophysiologic
mechanisms and increased oxidative stress has been viewed as one of the potential …
mechanisms and increased oxidative stress has been viewed as one of the potential …
Vitamin D and endothelial function
Vitamin D is known to elicit a vasoprotective effect, while vitamin D deficiency is a risk factor
for endothelial dysfunction (ED). ED is characterized by reduced bioavailability of a potent …
for endothelial dysfunction (ED). ED is characterized by reduced bioavailability of a potent …
RIPK1 Expression Associates With Inflammation in Early Atherosclerosis in Humans and Can Be Therapeutically Silenced to Reduce NF-κB Activation and …
D Karunakaran, MA Nguyen, M Geoffrion, D Vreeken… - Circulation, 2021 - Am Heart Assoc
Background: Chronic activation of the innate immune system drives inflammation and
contributes directly to atherosclerosis. We previously showed that macrophages in the …
contributes directly to atherosclerosis. We previously showed that macrophages in the …
The NLRP3 inflammasome and the emerging role of colchicine to inhibit atherosclerosis-associated inflammation
Atherosclerosis is considered a chronic inflammatory disease of the arterial wall. Recently,
compelling evidence has arisen for the role of monocytes and neutrophils and a particular …
compelling evidence has arisen for the role of monocytes and neutrophils and a particular …
Polymeric nanostructures for imaging and therapy
Medical diagnosis and therapy are essential for providing patients with proper care,
although inefficient diagnosis and therapy are usually associated with either improper …
although inefficient diagnosis and therapy are usually associated with either improper …
Phospholipase A2 Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention
1.1. Discovery of the Phospholipase A2 Superfamily Phospholipases represent one of the
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …
[HTML][HTML] Molecularly targeted nanomedicine enabled by inorganic nanoparticles for atherosclerosis diagnosis and treatment
Atherosclerosis, a chronic cardiovascular disease caused by plaque development in
arteries, remains a leading cause of morbidity and mortality. Atherosclerotic plaques are …
arteries, remains a leading cause of morbidity and mortality. Atherosclerotic plaques are …
Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009
RA DeFronzo - Diabetologia, 2010 - Springer
Insulin resistance is a hallmark of type 2 diabetes mellitus and is associated with a metabolic
and cardiovascular cluster of disorders (dyslipidaemia, hypertension, obesity [especially …
and cardiovascular cluster of disorders (dyslipidaemia, hypertension, obesity [especially …
Dapagliflozin exerts anti-inflammatory effects via inhibition of LPS-induced TLR-4 overexpression and NF-κB activation in human endothelial cells and differentiated …
E Abdollahi, F Keyhanfar, AA Delbandi, R Falak… - European Journal of …, 2022 - Elsevier
Evidence has demonstrated that a new class of anti-diabetic drugs, sodium-glucose co-
transporter 2 (SGLT2) inhibitors, could exert beneficial effects on atherosclerotic …
transporter 2 (SGLT2) inhibitors, could exert beneficial effects on atherosclerotic …
Monocytes in coronary artery disease and atherosclerosis: where are we now?
Despite improvements in interventional and pharmacological therapy of atherosclerotic
disease, it is still the leading cause of death in the developed world. Hence, there is a need …
disease, it is still the leading cause of death in the developed world. Hence, there is a need …