[HTML][HTML] Harmonizing the craft of crafting clinically endorsed small-molecule BCR-ABL tyrosine kinase inhibitors for the treatment of hematological malignancies

L Sun, PC Yang, L Luan, JF Sun, YT Wang - European Journal of …, 2024 - Elsevier
The advancement and practical use of small-molecule tyrosine kinase inhibitors (TKIs) that
specifically target the BCR-ABL fusion protein have introduced a revolutionary era of …

Dynamic DNA networks-guided directional and orthogonal transient biocatalytic cascades

Y Ouyang, J Dong, I Willner - Journal of the American Chemical …, 2023 - ACS Publications
DNA frameworks, consisting of constitutional dynamic networks (CDNs) undergoing fuel-
driven reconfiguration, are coupled to a dissipative reaction module that triggers the …

Recent advance of clinically approved small-molecule drugs for the treatment of myeloid leukemia

ZX Niu, YT Wang, JF Sun, P Nie, P Herdewijn - European Journal of …, 2023 - Elsevier
Myeloid leukemia denotes a hematologic malignancy characterized by aberrant proliferation
and impaired differentiation of blood progenitor cells within the bone marrow. Despite the …

Highly efficient photoelectrochemical aptasensor based on CdS/CdTe QDs co-sensitized TiO2 nanoparticles designed for thrombin detection

X Xu, Y Lu, D Liu, L Zhang, L Zheng, G Nie - Microchimica Acta, 2024 - Springer
A photoelectrochemical (PEC) sensor for the sensitive detection of thrombin (TB) was
established. Co-sensitized combination of TiO2 nanoparticles combined with modified …

Photochemically Triggered, Transient, and Oscillatory Transcription Machineries Guide Temporal Modulation of Fibrinogenesis

J Dong, I Willner - Journal of the American Chemical Society, 2024 - ACS Publications
Photochemically triggered, transient, and temporally oscillatory-modulated transcription
machineries are introduced. The resulting dynamic transcription circuits are implemented to …

Photochemically Triggered and Autonomous Oscillatory pH‐Modulated Transient Assembly/Disassembly of DNA Microdroplet Coacervates

Y Qin, YS Sohn, X Li, R Nechushtai… - Angewandte …, 2024 - Wiley Online Library
The assembly of pH‐responsive DNA‐based, phase‐separated microdroplets (MDs)
coacervates, consisting of frameworks composed of Y‐shaped nucleic acid modules …

Polymerase‐Based Signal Delay for Temporally Regulating DNA Involved Reactions, Programming Dynamic Molecular Systems, and Biomimetic Sensing

Q Rong, Y Deng, F Chen, Z Yin, L Hu, X Su, D Zhou - Small, 2024 - Wiley Online Library
Complex temporal molecular signals play a pivotal role in the intricate biological pathways
of living organisms, and cells exhibit the ability to transmit and receive information by …

DNA Nanostructures‐Based In Situ Cancer Vaccines: Mechanisms and Applications

B Lin, Y Liu, Q Chen, M Li, L Xu, Q Chen, Y Tan… - Small …, 2025 - Wiley Online Library
Current tumor vaccines suffer from inadequate immune responsive due to the insufficient
release of tumor antigens, low tumor infiltration, and immunosuppressive microenvironment …