Next-generation sequencing allows the analysis of genomes, including those representing
disease states. However, the causes of most disorders are multifactorial, and systems-level …

Systems biology requires comprehensive data at all molecular levels. Mass spectrometry
(MS)-based proteomics has emerged as a powerful and universal method for the global …

Elucidating the wiring diagram of the human cell is a central goal of the postgenomic era.
We combined genome engineering, confocal live-cell imaging, mass spectrometry, and data …

The intraluminal vesicles (ILVs) of endosomes mediate the delivery of activated signaling
receptors and other proteins to lysosomes for degradation, but they also modulate …

Pyroptosis is a lytic form of cell death that is induced by inflammatory caspases upon
activation of the canonical or noncanonical inflammasome pathways. These caspases …

Proteins such as FUS phase separate to form liquid-like condensates that can harden into
less dynamic structures. However, how these properties emerge from the collective …

Prion-like RNA binding proteins (RBPs) such as TDP43 and FUS are largely soluble in the
nucleus but form solid pathological aggregates when mislocalized to the cytoplasm. What …

Although lysosomes perform a number of essential cellular functions, damaged lysosomes
represent a potential hazard to the cell. Such lysosomes are therefore engulfed by …

Although PARP inhibitors (PARPi) target homologous recombination defective tumours,
drug resistance frequently emerges, often via poorly understood mechanisms. Here, using …

Stress granules (SG) are membrane‐less compartments involved in regulating mRNAs
during stress. Aberrant forms of SGs have been implicated in age‐related diseases, such as …