Asthma is characterized by airway inflammation rich in eosinophils. Airway eosinophilia is
associated with exacerbations and has been suggested to play a role in airway remodelling …

Integrins are cell adhesion receptors that communicate biochemical and mechanical signals
in a bidirectional manner across the plasma membrane and thus influence most cellular …

In multiple sclerosis, brain-reactive T cells invade the central nervous system (CNS) and
induce a self-destructive inflammatory process. T-cell infiltrates are not only found within the …

Angiopoietin-2 (ANG-2) is a key regulator of angiogenesis that exerts context-dependent
effects on ECs. ANG-2 binds the endothelial-specific receptor tyrosine kinase 2 (TIE2) and …

Fluid shear stress is a critical determinant of vascular remodeling and atherogenesis. Both
integrins and the small GTPase Rho are implicated in endothelial cell responses to shear …

Tumor inflammation promotes angiogenesis, immunosuppression, and tumor growth, but the
mechanisms controlling inflammatory cell recruitment to tumors are not well understood. We …

The mechanism by which ECM elasticity induces lineage specification of stem cells has not
been clearly understood. Integrins are well-documented mechanosensors that are …

Recognition of laminin by integrin receptors is central to the epithelial cell adhesion to
basement membrane, but the structural background of this molecular interaction remained …

The aim of this study is to elucidate the role of integrins in transducing fluid shear stress into
intracellular signals in vascular endothelial cells, a fundamental process in vascular biology …

Using a high-throughput chemical screen, we identified two small molecules that enhance
the survival of human embryonic stem cells (hESCs). By characterizing their mechanisms of …