Antipsychotics, metabolic adverse effects, and cognitive function in schizophrenia
NE MacKenzie, C Kowalchuk, SM Agarwal… - Frontiers in …, 2018 - frontiersin.org
Cognitive impairment is a core symptom domain of schizophrenia. The effect of
antipsychotics, the cornerstone of treatment in schizophrenia, on this domain is not fully …
antipsychotics, the cornerstone of treatment in schizophrenia, on this domain is not fully …
The role of long-acting injectable antipsychotics in schizophrenia: a critical appraisal
Despite their widespread use, long-acting injectable (LAI) antipsychotics (APs) are often
regarded with some negativity because of the assumption of punishment, control and …
regarded with some negativity because of the assumption of punishment, control and …
Myelin, myelin-related disorders, and psychosis
The neuropathological basis of schizophrenia and related psychoses remains elusive
despite intensive scientific investigation. Symptoms of psychosis have been reported in a …
despite intensive scientific investigation. Symptoms of psychosis have been reported in a …
Oligodendroglial alterations and the role of microglia in white matter injury: relevance to schizophrenia
LJ Chew, P Fusar-Poli, T Schmitz - Developmental neuroscience, 2013 - karger.com
Schizophrenia is a chronic and debilitating mental illness characterized by a broad range of
abnormal behaviors, including delusions and hallucinations, impaired cognitive function, as …
abnormal behaviors, including delusions and hallucinations, impaired cognitive function, as …
Multimodal magnetic resonance imaging assessment of white matter aging trajectories over the lifespan of healthy individuals
G Bartzokis, PH Lu, P Heydari, A Couvrette, GJ Lee… - Biological …, 2012 - Elsevier
BACKGROUND: Postmortem and volumetric imaging data suggest that brain myelination is
a dynamic lifelong process that, in vulnerable late-myelinating regions, peaks in middle age …
a dynamic lifelong process that, in vulnerable late-myelinating regions, peaks in middle age …
Long-acting injectable antipsychotics for early psychosis: a comprehensive systematic review
L Lian, DD Kim, RM Procyshyn, D Cázares… - PLoS …, 2022 - journals.plos.org
Aim Long acting injectable (LAI) antipsychotics are an alternative to oral antipsychotic (OAP)
treatment and may be beneficial for patients in the early stages of schizophrenia. This study …
treatment and may be beneficial for patients in the early stages of schizophrenia. This study …
Neuroglialpharmacology: myelination as a shared mechanism of action of psychotropic treatments
G Bartzokis - Neuropharmacology, 2012 - Elsevier
Current psychiatric diagnostic schema segregate symptom clusters into discrete entities,
however, large proportions of patients suffer from comorbid conditions that fit neither …
however, large proportions of patients suffer from comorbid conditions that fit neither …
White matter changes associated with antipsychotic treatment in first-episode psychosis
Second-generation antipsychotics are utilized extensively in the treatment of psychotic
disorders and other psychiatric conditions, but the effects of these medications on human …
disorders and other psychiatric conditions, but the effects of these medications on human …
Clinical benefits and impact of early use of long‐acting injectable antipsychotics for schizophrenia
GL Stevens, G Dawson, J Zummo - Early intervention in …, 2016 - Wiley Online Library
Aim Results from clinical trials support the use of oral antipsychotics for treatment of early or
first‐episode psychosis in patients with schizophrenia. This paper will review literature on …
first‐episode psychosis in patients with schizophrenia. This paper will review literature on …
The effect of longer dosing intervals for long-acting injectable antipsychotics on outcomes in schizophrenia
R Milz, C Benson, K Knight, J Antunes… - Neuropsychiatric …, 2023 - Taylor & Francis
Medication nonadherence in schizophrenia can have serious implications including
relapses and hospitalization. Long-acting injectable (LAI) antipsychotics require fewer …
relapses and hospitalization. Long-acting injectable (LAI) antipsychotics require fewer …