The microtubule-based spindle orchestrates chromosome segregation during cell division.
Following more than a century of study, many components and pathways contributing to …

Life depends on cell proliferation and the accurate segregation of chromosomes, which are
mediated by the microtubule (MT)-based mitotic spindle and∼ 200 essential MT-associated …

INTRODUCTION The microtubule cytoskeleton is continuously sculpted by polymerization,
depolymerization, cross-linking, and microtubule severing. Microtubule severing generates …

Microtubule-severing enzymes are critical for the biogenesis and maintenance of complex
microtubule arrays in axons, spindles, and cilia where tubulin detyrosination, acetylation …

Microtubule severing was first reported in Xenopus laevis egg extracts (Vale, 1991). The first
microtubule-severing enzyme was purified from sea urchin eggs (McNally and Vale, 1993) …

© 2012 Marshall et al; licensee BioMed Central Ltd. This is an Open Access article
distributed under the terms of the Creative Commons Attribution License (http …

Despite their overwhelming complexity, living cells display a high degree of internal
mechanical and functional organization which can largely be attributed to the intracellular …

Rapid and reductive cell divisions during embryogenesis require that intracellular structures
adapt to a wide range of cell sizes. The mitotic spindle presents a central example of this …

ASPM (known as Asp in fly and ASPM-1 in worm) is a microcephaly-associated protein
family that regulates spindle architecture, but the underlying mechanism is poorly …

Microtubule-severing enzymes–katanin, spastin, fidgetin–are related AAA-ATPases that cut
microtubules into shorter filaments. These proteins, also called severases, are involved in a …