Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25
The calcitonin/CGRP family of peptides includes calcitonin, α and β CGRP, amylin,
adrenomedullin (AM) and adrenomedullin 2/intermedin (AM2/IMD). Their receptors consist …
adrenomedullin (AM) and adrenomedullin 2/intermedin (AM2/IMD). Their receptors consist …
Vascular actions of calcitonin gene-related peptide and adrenomedullin
SD Brain, AD Grant - Physiological reviews, 2004 - journals.physiology.org
This review summarizes the receptor-mediated vascular activities of calcitonin gene-related
peptide (CGRP) and the structurally related peptide adrenomedullin (AM). CGRP is a 37 …
peptide (CGRP) and the structurally related peptide adrenomedullin (AM). CGRP is a 37 …
A structural basis for amylin receptor phenotype
Amylin receptors (AMYRs) are heterodimers of the calcitonin (CT) receptor (CTR) and one of
three receptor activity–modifying proteins (RAMPs), AMY1R, AMY2R, and AMY3R. Selective …
three receptor activity–modifying proteins (RAMPs), AMY1R, AMY2R, and AMY3R. Selective …
Neuropeptides, food intake and body weight regulation: a hypothalamic focus
JJG Hillebrand, D De Wied, RAH Adan - Peptides, 2002 - Elsevier
Energy homeostasis is controlled by a complex neuroendocrine system consisting of
peripheral signals like leptin and central signals, in particular, neuropeptides. Several …
peripheral signals like leptin and central signals, in particular, neuropeptides. Several …
The anorectic effect of a chronic peripheral infusion of amylin is abolished in area postrema/nucleus of the solitary tract (AP/NTS) lesioned rats
TA Lutz, A Mollet, PA Rushing, T Riediger… - International journal of …, 2001 - nature.com
OBJECTIVE: Neurons in the area postrema/nucleus of the solitary tract (AP/NTS) region
mediate amylin's anorectic effect elicited by a single intraperitoneal (ip) injection of a low …
mediate amylin's anorectic effect elicited by a single intraperitoneal (ip) injection of a low …
Mediators of amylin action in metabolic control
Amylin (also called islet amyloid polypeptide (IAPP)) is a pancreatic beta-cell hormone that
is co-secreted with insulin in response to nutrient stimuli. The last 35 years of intensive …
is co-secreted with insulin in response to nutrient stimuli. The last 35 years of intensive …
[HTML][HTML] Gut-brain axis and addictive disorders: A review with focus on alcohol and drugs of abuse
E Jerlhag - Pharmacology & Therapeutics, 2019 - Elsevier
Due to the limited efficacy of existing medications for addictive disorders including alcohol
use disorder (AUD), the need for additional medications is substantial. Potential new …
use disorder (AUD), the need for additional medications is substantial. Potential new …
Control of energy homeostasis by amylin
TA Lutz - Cellular and molecular life sciences, 2012 - Springer
Amylin is an important control of nutrient fluxes because it reduces energy intake, modulates
nutrient utilization by inhibiting postprandial glucagon secretion, and increases energy …
nutrient utilization by inhibiting postprandial glucagon secretion, and increases energy …
Amylin and calcitonin: potential therapeutic strategies to reduce body weight and liver fat
The hormones amylin and calcitonin interact with receptors within the same family to exert
their effects on the human organism. Calcitonin, derived from thyroid C cells, is known for its …
their effects on the human organism. Calcitonin, derived from thyroid C cells, is known for its …
Infusion of the amylin antagonist AC 187 into the area postrema increases food intake in rats
A Mollet, S Gilg, T Riediger, TA Lutz - Physiology & behavior, 2004 - Elsevier
According to previous studies, the area postrema (AP) of the hindbrain may play an
important role in mediating the anorectic effect of the pancreatic hormone amylin. Peripheral …
important role in mediating the anorectic effect of the pancreatic hormone amylin. Peripheral …