The brain of modern humans has evolved remarkable computational abilities that enable
higher cognitive functions. These capacities are tightly linked to an increase in the size and …

The human DEAD-box protein DDX3X is an RNA remodelling enzyme that has been
implicated in various aspects of RNA metabolism. In addition, like many DEAD-box proteins …

For many decades to date, neuroendocrinologists have delved into the key contribution of
gonadal hormones to the generation of sex differences in the develo** brain and the …

Since the beautiful images of Santiago Ramón y Cajal provided a first glimpse into the
immense diversity and complexity of cell types found in the cerebral cortex, neuroscience …

Neurogenesis, the process of generating neurons from neural stem cells, occurs during both
embryonic and adult stages, with each stage possessing distinct characteristics. Dysfunction …

Highlights•Chromosome X is enriched for genes associated with neurodevelopmental
disorders.•X chromosome inactivation evolved to harmonize gene dosage across …

The Y-linked gene DDX3Y and its X-linked homolog DDX3X survived the evolution of the
human sex chromosomes from ordinary autosomes. DDX3X encodes a multifunctional RNA …

RNA splicing is highly prevalent in the brain and has strong links to neuropsychiatric
disorders; yet, the role of cell type–specific splicing and transcript-isoform diversity during …

DEAD-box helicases are global regulators of liquid-liquid phase separation (LLPS), a
process that assembles membraneless organelles inside cells. An outstanding member of …

Humans evolved an extraordinarily expanded and complex cerebral cortex, associated with
developmental and gene regulatory modifications–. Human accelerated regions (HARs) are …