SUMMARY β-Lactam antibiotics have been widely used as therapeutic agents for the past
70 years, resulting in emergence of an abundance of β-lactam-inactivating β-lactamases …

Species identification by using matrix-assisted laser desorption/ionization time-of-flight mass
spectrometry (MALDI-TOF MS) is a routine diagnostic process for infectious diseases in …

Once hailed as miraculous solutions, antibiotics no longer hold that status. The excessive
use of antibiotics across human healthcare, agriculture, and animal husbandry has given …

Klebsiella pneumoniae as a main opportunistic pathogen is a common cause of health-care-
associated bacterial infections, which has shown high levels of drug resistance specifically …

In humans, more than three hundred diverse enzymes that require zinc as an essential
cofactor have been identified. These zinc enzymes have demonstrated different and …

Metallo-β-lactamases (MBLs) contribute to the resistance of Gram-negative bacteria to
carbapenems, last-resort antibiotics at hospital, and MBL inhibitors are urgently needed to …

β-lactamase enzymes have generated significant interest due to their ability to confer
resistance to the most commonly used family of antibiotics in human medicine. Among these …

Abstract β-lactam antibiotics are the most successful and commonly used antibacterial
agents, but the emergence of resistance to these drugs has become a global health threat …

Gram‐negative bacterial infections are a global health problem. The production of beta‐
lactamase is still the most vital factor leading to beta‐lactam resistance. In Trinidad and …

According to the World Health Organization, antibiotic resistance is a global health threat. Of
particular importance are infections caused by multidrug-resistant Gram-negative bacteria …