The brain reward circuitry in mood disorders

SJ Russo, EJ Nestler - Nature reviews neuroscience, 2013 - nature.com
Mood disorders are common and debilitating conditions characterized in part by profound
deficits in reward-related behavioural domains. A recent literature has identified important …

Stress and the dopaminergic reward system

JH Baik - Experimental & molecular medicine, 2020 - nature.com
Dopamine regulates reward-related behavior through the mesolimbic dopaminergic
pathway. Stress affects dopamine levels and dopaminergic neuronal activity in the …

Interface engineering of highly efficient perovskite solar cells

H Zhou, Q Chen, G Li, S Luo, T Song, HS Duan… - Science, 2014 - science.org
Advancing perovskite solar cell technologies toward their theoretical power conversion
efficiency (PCE) requires delicate control over the carrier dynamics throughout the entire …

Frontostriatal salience network expansion in individuals in depression

CJ Lynch, IG Elbau, T Ng, A Ayaz, S Zhu, D Wolk… - Nature, 2024 - nature.com
Decades of neuroimaging studies have shown modest differences in brain structure and
connectivity in depression, hindering mechanistic insights or the identification of risk factors …

Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation

RN Moda-Sava, MH Murdock, PK Parekh, RN Fetcho… - Science, 2019 - science.org
INTRODUCTION Depression is an episodic form of mental illness, yet the circuit-level
mechanisms driving the induction, remission, and recurrence of depressive episodes over …

Long-range and local circuits for top-down modulation of visual cortex processing

S Zhang, M Xu, T Kamigaki, JP Hoang Do, WC Chang… - science, 2014 - science.org
Top-down modulation of sensory processing allows the animal to select inputs most relevant
to current tasks. We found that the cingulate (Cg) region of the mouse frontal cortex …

Pathogenesis of depression: insights from human and rodent studies

C Ménard, GE Hodes, SJ Russo - Neuroscience, 2016 - Elsevier
Major depressive disorder (MDD) will affect one out of every five people in their lifetime and
is the leading cause of disability worldwide. Nevertheless, mechanisms associated with the …

Prefrontal cortical regulation of brainwide circuit dynamics and reward-related behavior

EA Ferenczi, KA Zalocusky, C Liston, L Grosenick… - Science, 2016 - science.org
INTRODUCTION The drive to seek and experience reward is conserved across species and,
in mammals, involves interactions between subcortical dopaminergic systems and limbic …

Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression

RC Bagot, EM Parise, CJ Pena, HX Zhang… - Nature …, 2015 - nature.com
Enhanced glutamatergic transmission in the nucleus accumbens (NAc), a region critical for
reward and motivation, has been implicated in the pathophysiology of depression; however …

Dendritic spines in depression: what we learned from animal models

H Qiao, MX Li, C Xu, HB Chen, SC An… - Neural plasticity, 2016 - Wiley Online Library
Depression, a severe psychiatric disorder, has been studied for decades, but the underlying
mechanisms still remain largely unknown. Depression is closely associated with alterations …