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Modulation of P-glycoprotein efflux pump: induction and activation as a therapeutic strategy
Abstract P-glycoprotein (P-gp) is an ATP-dependent efflux pump encoded by the MDR1
gene in humans, known to mediate multidrug resistance of neoplastic cells to cancer …
gene in humans, known to mediate multidrug resistance of neoplastic cells to cancer …
[HTML][HTML] Cellular models and in vitro assays for the screening of modulators of P-gp, MRP1 and BCRP
Adenosine triphosphate (ATP)-binding cassette (ABC) transporters are highly expressed in
tumor cells, as well as in organs involved in absorption and secretion processes, mediating …
tumor cells, as well as in organs involved in absorption and secretion processes, mediating …
[HTML][HTML] Study models of drug–drug interactions involving p-glycoprotein: the potential benefit of p-glycoprotein modulation at the kidney and intestinal levels
P-glycoprotein (P-gp) is a crucial membrane transporter situated on the cell's apical surface,
being responsible for eliminating xenobiotics and endobiotics. P-gp modulators are …
being responsible for eliminating xenobiotics and endobiotics. P-gp modulators are …
Interactions of pesticides with membrane drug transporters: implications for toxicokinetics and toxicity
Introduction: Drug transporters are now recognized as major actors of pharmacokinetics.
They are also likely implicated in toxicokinetics and toxicology of environmental pollutants …
They are also likely implicated in toxicokinetics and toxicology of environmental pollutants …
P-glycoprotein induction in Caco-2 cells by newly synthetized thioxanthones prevents paraquat cytotoxicity
The induction of P-glycoprotein (P-gp), an ATP-dependent efflux pump, has been proposed
as a strategy against the toxicity induced by P-gp substrates such as the herbicide paraquat …
as a strategy against the toxicity induced by P-gp substrates such as the herbicide paraquat …
Rifampin regulation of drug transporters gene expression and the association of microRNAs in human hepatocytes
Membrane drug transporters contribute to the disposition of many drugs. In human liver,
drug transport is controlled by two main superfamilies of transporters, the solute carrier …
drug transport is controlled by two main superfamilies of transporters, the solute carrier …
Xanthones as P-glycoprotein modulators and their impact on drug bioavailability
V Silva, E Gil-Martins, B Silva… - Expert Opinion on …, 2021 - Taylor & Francis
ABSTRACT Introduction: P-glycoprotein (P-gp) is an important efflux pump responsible for
the extruding of many endogenous and exogenous substances out of the cells. P-gp can be …
the extruding of many endogenous and exogenous substances out of the cells. P-gp can be …
Induction and activation of P-glycoprotein by dihydroxylated xanthones protect against the cytotoxicity of the P-glycoprotein substrate paraquat
Xanthones are a family of compounds with several known biological activities and
therapeutic potential for which information on their interaction with membrane transporters is …
therapeutic potential for which information on their interaction with membrane transporters is …
Organic anion-transporting polypeptide genes are not induced by the pregnane X receptor activator rifampin: studies in hepatocytes in vitro and in monkeys in vivo
C Niu, Y Wang, X Zhao, S Tep, E Murakami… - Drug Metabolism and …, 2019 - Elsevier
Induction potentials of the pregnane X receptor (PXR) activator rifampin (RIF) on transporter
genes [eg, organic anion-transporting polypeptides (OATPs)] are still in its infancy or remain …
genes [eg, organic anion-transporting polypeptides (OATPs)] are still in its infancy or remain …
[HTML][HTML] Cardiac PET imaging of ATP binding cassette (ABC) transporters: opportunities and challenges
Adenosine triphosphate binding cassette (ABC) transporters are a broad family of
membrane protein complexes that use energy to transport molecules across cells and/or …
membrane protein complexes that use energy to transport molecules across cells and/or …