Timing of lifespan influences on brain and cognition

KB Walhovd, M Lövden, AM Fjell - Trends in cognitive sciences, 2023 - cell.com
Modifiable risk and protective factors for boosting brain and cognitive development and
preventing neurodegeneration and cognitive decline are embraced in neuroimaging …

A perspective on brain-age estimation and its clinical promise

C Gaser, P Kalc, JH Cole - Nature computational science, 2024 - nature.com
Brain-age estimation has gained increased attention in the neuroscientific community owing
to its potential use as a biomarker of brain health. The difference between estimated and …

Brain aerobic glycolysis and resilience in Alzheimer disease

MS Goyal, T Blazey, NV Metcalf, MP McAvoy… - Proceedings of the …, 2023 - pnas.org
The distribution of brain aerobic glycolysis (AG) in normal young adults correlates spatially
with amyloid-beta (Aβ) deposition in individuals with symptomatic and preclinical Alzheimer …

Biological brain age prediction using machine learning on structural neuroimaging data: Multi-cohort validation against biomarkers of Alzheimer's disease and …

I Cumplido-Mayoral, M García-Prat, G Operto, C Falcon… - Elife, 2023 - elifesciences.org
Brain-age can be inferred from structural neuroimaging and compared to chronological age
(brain-age delta) as a marker of biological brain aging. Accelerated aging has been found in …

Developmental prediction modeling based on diffusion tensor imaging uncovering age-dependent heterogeneity in early childhood autistic brain

X Huang, Y Ming, W Zhao, R Feng, Y Zhou, L Wu… - Molecular Autism, 2023 - Springer
Objective There has been increasing evidence for atypical white matter (WM) microstructure
in autistic people, but findings have been divergent. The development of autistic people in …

[HTML][HTML] Why is iron deficiency/anemia linked to Alzheimer's disease and its comorbidities, and how is it prevented?

K Fehsel - Biomedicines, 2023 - mdpi.com
Impaired iron metabolism has been increasingly observed in many diseases, but a deeper,
mechanistic understanding of the cellular impact of altered iron metabolism is still lacking. In …

Brain age as a biomarker for pathological versus healthy ageing–a REMEMBER study

MMJ Wittens, S Denissen, DM Sima, E Fransen… - Alzheimer's research & …, 2024 - Springer
Objectives This study aimed to evaluate the potential clinical value of a new brain age
prediction model as a single interpretable variable representing the condition of our brain …

Interdisciplinary fetal-neonatal neurology training improves brain health across the lifespan

MS Scher - Frontiers in Neurology, 2024 - frontiersin.org
Integrated fetal, neonatal, and pediatric training constitute an interdisciplinary fetal-neonatal
neurology (FNN) program. A dynamic neural exposome concept strengthens curriculum …

Advanced structural brain aging in preclinical autosomal dominant Alzheimer disease

PR Millar, BA Gordon, JK Wisch, SA Schultz… - Molecular …, 2023 - Springer
Background “Brain-predicted age” estimates biological age from complex, nonlinear
features in neuroimaging scans. The brain age gap (BAG) between predicted and …

Considerations on brain age predictions from repeatedly sampled data across time

M Korbmacher, MY Wang, R Eikeland… - Brain and …, 2023 - Wiley Online Library
Introduction Brain age, the estimation of a person's age from magnetic resonance imaging
(MRI) parameters, has been used as a general indicator of health. The marker requires …