Recently, we reported that two homologous yeast proteins, Rai1 and Dxo1, function in a
quality control mechanism to clear cells of incompletely 5′ end-capped messenger RNAs …

The transcription cycle of RNA polymerase II (Pol II) is regulated at discrete transition points
by cyclin-dependent kinases (CDKs). Positive transcription elongation factor b (P-TEFb), a …

Ribonucleases J1 and J2 are recently discovered enzymes with dual 5′‐to‐3′
exoribonucleolytic/endoribonucleolytic activity that plays a key role in the maturation and …

Recent studies showed that Rai1 is a crucial component of the mRNA 5′-end-cap**
quality-control mechanism in yeast. The yeast genome encodes a weak homolog of Rai1 …

Abstract Metallo‐β‐lactamases (MBLs) cause resistance of Gram‐negative bacteria to β‐
lactam antibiotics and are of serious concern, because they can inactivate the last‐resort …

RNase J is a key member of the β-CASP family of metallo-β-lactamases involved in the
maturation and turnover of RNAs in prokaryotes. The B. subtilis enzyme possesses both 5 …

Modifications at the 5′-end of RNAs play a pivotal role in determining their fate. In
eukaryotes, the DXO/Rai1 family of enzymes removes numerous 5′-end RNA …

CPSF73 is the endonuclease that catalyzes the cleavage reaction for 3′-end processing of
mRNA precursors (pre-mRNAs) in two distinct machineries, a canonical machinery for the …

The scavenger decap** enzyme Dcs1 has been shown to facilitate the activity of the
cytoplasmic 5′-3′ exoribonuclease Xrn1 in eukaryotes. Dcs1 has also been shown to be …

XRN2 is an essential eukaryotic exoribonuclease that processes and degrades various
substrates. Here we identify the previously uncharacterized protein R05D11. 6/PAXT-1 as a …