The enigma of transcriptional activation domains

AM Erkine, MA Oliveira, CA Class - Journal of Molecular Biology, 2024 - Elsevier
Highlights•Transcriptional ADs are extremely variable in sequence, structure, and
interactions.•The recruitment of coactivators by ADs requires specificity, thus is …

Parasitoid Serpins Evolve Novel Functions to Manipulate Host Homeostasis

Z Wu, R Yuan, Q Gu, X Wu, L Gu, X Ye… - Molecular Biology …, 2023 - academic.oup.com
Parasitoids introduce various virulence factors when parasitism occurs, and some taxa
generate teratocytes to manipulate the host immune system and metabolic homeostasis for …

Gene essentiality and variability: What is the link? A within‐and between‐species perspective

T Dubois‐Mignon, P Monget - BioEssays, 2022 - Wiley Online Library
A gene is considered essential when its loss of function results in a deleterious phenotype,
hugely reducing the organism's viability or fitness. However, the link between the essentiality …

Number of human protein interactions correlates with structural, but not regulatory conservation of the respective genes

R Mekic, MA Zolotovskaia, M Sorokin… - Frontiers in …, 2024 - frontiersin.org
Introduction The differential ratio of nonsynonymous to synonymous nucleotide substitutions
(dN/dS) is a common measure of the rate of structural evolution in proteincoding genes. In …

MORC2 restriction factor silences HIV proviral expression

A Lasserre, S Marie, M Morel, MM Martin, A Legrand… - bioRxiv, 2023 - biorxiv.org
The HUSH complex (composed of TASOR, MPP8 and periphilin) represses HIV-1
expression from its promoter by inducing both propagation of repressive epigenetic marks …

Composition Diversity and Expression Specificity of the TPS Gene Family among 24 Ficus Species

P Sun, X Chen, B Chantarasuwan, X Zhu, X Deng… - Diversity, 2022 - mdpi.com
Volatile organic compounds (VOCs) released by the receptive syconia of Ficus species play
a vital role in attracting highly species-specific pollinating fig wasps. The components of …

Deciphering the complete plastid genome of an endemic monotypic species Kostermansia malayana (Malvaceae) from Peninsular Malaysia: structural comparative …

XJ Wong, SD Ramaiya, WH Cheng, A Faizal… - Botany, 2024 - cdnsciencepub.com
Kostermansia malayana Soegeng, a species of Malvaceae endemic to the Malay Peninsula,
is threatened by its rare flowering rate and habitat loss due to agriculture land conversion …

Regulatory networks of KRAB zinc finger genes and transposable elements changed during human brain evolution and disease

YC Chen, A Maupas, K Nowick - bioRxiv, 2023 - biorxiv.org
Transposable elements (TEs), with their ability to change positions within a genome, have
paradoxically been seen as both a potentially deleterious genomic phenomenon and a …

Quelle relation existe-t-il entre l'importance fonctionnelle d'un gène et son degré de polymorphisme? Un point de vue intra-et interespèces

P Monget - Bulletin de l'Académie Nationale de Médecine, 2023 - Elsevier
Résumé Un gène est considéré comme essentiel ou important d'un point de vue fonctionnel
lorsque sa perte de fonction entraîne un phénotype morbide ou létal, selon la …