Systems analyses have facilitated the characterization of metabolic networks of several
organisms. We have reconstructed the metabolic network of Leishmania major, a poorly …

Importance of the field: Parasitic diseases that pose a threat to human life include
leishmaniasis–caused by protozoa of Leishmania species. Existing drugs have limitations …

To facilitate a greater understanding of the biological processes in the medically important
Leishmania donovani parasite, a combination of differential and density-gradient …

Glucokinase genes, found in the genome databases of Trypanosoma cruzi and Leishmania
major, were cloned and sequenced. Their expression in Escherichia coli resulted in the …

Hexokinase from Leishmania mexicana was purified to homogeneity from a glycosome-
enriched fraction obtained after a differential centrifugation of promastigote form. The kinetic …

Kinetoplastid‐based infections are neglected diseases that represent a significant human
health issue. Chemotherapeutic options are limited due to toxicity, parasite susceptibility …

Hexokinase (HK) is one of the key enzymes in the glycolytic pathway that catalyzes the
phosphorylation of glucose. In the present study, we cloned the HK gene from the coccidian …

5′ EST from filarial gene database has been subjected to 3′ rapid amplification of cDNA
ends (RACE), semi-nested PCR and PCR to obtain full-length cDNA of Brugia malayi. Full …

Background/Objectives Palestinian strains of L. tropica characterized by multilocus enzyme
electrophoresis (MLEE) fall into two zymodemes, either MON-137 or MON-307 …

Glucokinase from pathogenic protozoa of the genus Leishmania is a potential drug target for
the chemotherapeutic treatment against leishmaniasis because this enzyme is located at a …