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[HTML][HTML] Functions and dysfunctions of nitric oxide in brain
P Picón-Pagès, J Garcia-Buendia, FJ Munoz - Biochimica et Biophysica …, 2019 - Elsevier
Nitric oxide (NO) works as a retrograde neurotransmitter in synapses, allows the brain blood
flow and also has important roles in intracellular signaling in neurons from the regulation of …
flow and also has important roles in intracellular signaling in neurons from the regulation of …
Gram-negative bacteria and their lipopolysaccharides in Alzheimer's disease: pathologic roles and therapeutic implications
Alzheimer's disease (AD) is the most serious age-related neurodegenerative disease and
causes destructive and irreversible cognitive decline. Failures in the development of …
causes destructive and irreversible cognitive decline. Failures in the development of …
Methylglyoxal metabolism and aging-related disease: moving from correlation toward causation
R Kold-Christensen, M Johannsen - Trends in Endocrinology & Metabolism, 2020 - cell.com
Methylglyoxal (MG) is a ubiquitous metabolite that spontaneously reacts with biopolymers
forming advanced glycation end-products (AGEs). AGEs are strongly associated with aging …
forming advanced glycation end-products (AGEs). AGEs are strongly associated with aging …
[HTML][HTML] Mitostasis, calcium and free radicals in health, aging and neurodegeneration
Mitochondria play key roles in ATP supply, calcium homeostasis, redox balance control and
apoptosis, which in neurons are fundamental for neurotransmission and to allow synaptic …
apoptosis, which in neurons are fundamental for neurotransmission and to allow synaptic …
Inhibition of neuroinflammatory nitric oxide signaling suppresses glycation and prevents neuronal dysfunction in mouse prion disease
Several neurodegenerative diseases associated with protein misfolding (Alzheimer's and
Parkinson's disease) exhibit oxidative and nitrergic stress following initiation of …
Parkinson's disease) exhibit oxidative and nitrergic stress following initiation of …
[HTML][HTML] The Dual Role of Amyloid Beta-Peptide in Oxidative Stress and Inflammation: Unveiling Their Connections in Alzheimer's Disease Etiopathology
H Fanlo-Ucar, P Picón-Pagès, V Herrera-Fernández… - Antioxidants, 2024 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease, and it is currently the
seventh leading cause of death worldwide. It is characterized by the extracellular …
seventh leading cause of death worldwide. It is characterized by the extracellular …
Carnosine and the processes of ageing
The causes of ageing are usually regarded as multifactorial; thus effective regulation might
be achieved by intervention at multiple sites. It has been suggested that the endogenous …
be achieved by intervention at multiple sites. It has been suggested that the endogenous …
Carbonyl stress in red blood cells and hemoglobin
OV Kosmachevskaya, NN Novikova, AF Topunov - Antioxidants, 2021 - mdpi.com
The paper overviews the peculiarities of carbonyl stress in nucleus-free mammal red blood
cells (RBCs). Some functional features of RBCs make them exceptionally susceptible to …
cells (RBCs). Some functional features of RBCs make them exceptionally susceptible to …
Amyloid-β peptide nitrotyrosination stabilizes oligomers and enhances NMDAR-mediated toxicity
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the pathological
aggregation of the amyloid-β peptide (Aβ). Monomeric soluble Aβ can switch from helicoidal …
aggregation of the amyloid-β peptide (Aβ). Monomeric soluble Aβ can switch from helicoidal …
Diet and obesity-induced methylglyoxal production and links to metabolic disease
The obesity rate in the United States is 42.4% and has become a national epidemic. Obesity
is a complex condition that is influenced by socioeconomic status, ethnicity, genetics, age …
is a complex condition that is influenced by socioeconomic status, ethnicity, genetics, age …