Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies

NK Singh, GN Rao - Progress in lipid research, 2019 - Elsevier
lipoxygenase (12/15-LOX) is an enzyme, which oxidizes polyunsaturated fatty acids,
particularly omega-6 and-3 fatty acids, to generate a number of bioactive lipid metabolites. A …

Functional and pathological roles of the 12-and 15-lipoxygenases

AD Dobrian, DC Lieb, BK Cole… - Progress in lipid …, 2011 - Elsevier
The 12/15-lipoxygenase enzymes react with fatty acids producing active lipid metabolites
that are involved in a number of significant disease states. The latter include type 1 and type …

VEGF-A links angiogenesis and inflammation in inflammatory bowel disease pathogenesis

F Scaldaferri, S Vetrano, M Sans, V Arena, G Straface… - Gastroenterology, 2009 - Elsevier
BACKGROUND & AIMS: Vascular endothelial growth factor A (VEGF-A) mediates
angiogenesis and might also have a role in inflammation and immunity. We examined …

Cyclooxygenases and lipoxygenases in cancer

C Schneider, A Pozzi - Cancer and Metastasis Reviews, 2011 - Springer
Cancer initiation and progression are multistep events that require cell proliferation,
migration, extravasation to the blood or lymphatic vessels, arrest to the metastatic site, and …

The discovery of the placental growth factor and its role in angiogenesis: a historical review

D Ribatti - Angiogenesis, 2008 - Springer
The placental growth factor (PlGF) is an angiogenic protein belonging to the vascular
endothelial growth factor (VEGF) family, which was discovered in 1991 by an Italian …

Emerging cellular functions of the lipid metabolizing enzyme 15‐Lipoxygenase‐1

M Çolakoğlu, S Tunçer, S Banerjee - Cell proliferation, 2018 - Wiley Online Library
The oxygenation of polyunsaturated fatty acids such as arachidonic and linoleic acid
through lipoxygenases (LOX s) and cyclooxygenases (COX s) leads to the production of …

[HTML][HTML] Endogenous LXA4 circuits are determinants of pathological angiogenesis in response to chronic injury

AJ Leedom, AB Sullivan, B Dong, D Lau… - The American journal of …, 2010 - Elsevier
Inflammation and angiogenesis are intimately linked, and their dysregulation leads to
pathological angiogenesis in human diseases. 15-lipoxygenase (15-LOX) and lipoxin A4 …

15-Lipoxygenase-1 as a tumor suppressor gene in colon cancer: is the verdict in?

S Il Lee, X Zuo, I Shureiqi - Cancer and Metastasis Reviews, 2011 - Springer
Lipoxygenase-1 (15-LOX-1) is an inducible and highly regulated enzyme in normal human
cells that plays a key role in the production of lipid signaling mediators, such as 13 …

Absence of glutathione peroxidase 4 affects tumor angiogenesis through increased 12/15-lipoxygenase activity

M Schneider, M Wortmann, PK Mandal… - Neoplasia, 2010 - Elsevier
The selenoenzyme glutathione peroxidase 4 (GPx4) has been described to control specific
cyclooxygenases (COXs) and lipoxygenases (LOXs) that exert substantiated functions in …

Bioactive lipid mediators in polycystic kidney disease

J Klawitter, J Klawitter, K McFann, AT Pennington… - Journal of lipid …, 2014 - ASBMB
Inflammatory activity is evident in patients with chronic kidney disease with limited data
available in autosomal dominant polycystic kidney disease (ADPKD). We hypothesized that …