Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies
NK Singh, GN Rao - Progress in lipid research, 2019 - Elsevier
lipoxygenase (12/15-LOX) is an enzyme, which oxidizes polyunsaturated fatty acids,
particularly omega-6 and-3 fatty acids, to generate a number of bioactive lipid metabolites. A …
particularly omega-6 and-3 fatty acids, to generate a number of bioactive lipid metabolites. A …
Functional and pathological roles of the 12-and 15-lipoxygenases
AD Dobrian, DC Lieb, BK Cole… - Progress in lipid …, 2011 - Elsevier
The 12/15-lipoxygenase enzymes react with fatty acids producing active lipid metabolites
that are involved in a number of significant disease states. The latter include type 1 and type …
that are involved in a number of significant disease states. The latter include type 1 and type …
VEGF-A links angiogenesis and inflammation in inflammatory bowel disease pathogenesis
BACKGROUND & AIMS: Vascular endothelial growth factor A (VEGF-A) mediates
angiogenesis and might also have a role in inflammation and immunity. We examined …
angiogenesis and might also have a role in inflammation and immunity. We examined …
Cyclooxygenases and lipoxygenases in cancer
C Schneider, A Pozzi - Cancer and Metastasis Reviews, 2011 - Springer
Cancer initiation and progression are multistep events that require cell proliferation,
migration, extravasation to the blood or lymphatic vessels, arrest to the metastatic site, and …
migration, extravasation to the blood or lymphatic vessels, arrest to the metastatic site, and …
The discovery of the placental growth factor and its role in angiogenesis: a historical review
D Ribatti - Angiogenesis, 2008 - Springer
The placental growth factor (PlGF) is an angiogenic protein belonging to the vascular
endothelial growth factor (VEGF) family, which was discovered in 1991 by an Italian …
endothelial growth factor (VEGF) family, which was discovered in 1991 by an Italian …
Emerging cellular functions of the lipid metabolizing enzyme 15‐Lipoxygenase‐1
The oxygenation of polyunsaturated fatty acids such as arachidonic and linoleic acid
through lipoxygenases (LOX s) and cyclooxygenases (COX s) leads to the production of …
through lipoxygenases (LOX s) and cyclooxygenases (COX s) leads to the production of …
[HTML][HTML] Endogenous LXA4 circuits are determinants of pathological angiogenesis in response to chronic injury
AJ Leedom, AB Sullivan, B Dong, D Lau… - The American journal of …, 2010 - Elsevier
Inflammation and angiogenesis are intimately linked, and their dysregulation leads to
pathological angiogenesis in human diseases. 15-lipoxygenase (15-LOX) and lipoxin A4 …
pathological angiogenesis in human diseases. 15-lipoxygenase (15-LOX) and lipoxin A4 …
15-Lipoxygenase-1 as a tumor suppressor gene in colon cancer: is the verdict in?
S Il Lee, X Zuo, I Shureiqi - Cancer and Metastasis Reviews, 2011 - Springer
Lipoxygenase-1 (15-LOX-1) is an inducible and highly regulated enzyme in normal human
cells that plays a key role in the production of lipid signaling mediators, such as 13 …
cells that plays a key role in the production of lipid signaling mediators, such as 13 …
Absence of glutathione peroxidase 4 affects tumor angiogenesis through increased 12/15-lipoxygenase activity
M Schneider, M Wortmann, PK Mandal… - Neoplasia, 2010 - Elsevier
The selenoenzyme glutathione peroxidase 4 (GPx4) has been described to control specific
cyclooxygenases (COXs) and lipoxygenases (LOXs) that exert substantiated functions in …
cyclooxygenases (COXs) and lipoxygenases (LOXs) that exert substantiated functions in …
Bioactive lipid mediators in polycystic kidney disease
J Klawitter, J Klawitter, K McFann, AT Pennington… - Journal of lipid …, 2014 - ASBMB
Inflammatory activity is evident in patients with chronic kidney disease with limited data
available in autosomal dominant polycystic kidney disease (ADPKD). We hypothesized that …
available in autosomal dominant polycystic kidney disease (ADPKD). We hypothesized that …