lipoxygenase (12/15-LOX) is an enzyme, which oxidizes polyunsaturated fatty acids,
particularly omega-6 and-3 fatty acids, to generate a number of bioactive lipid metabolites. A …

The 12/15-lipoxygenase enzymes react with fatty acids producing active lipid metabolites
that are involved in a number of significant disease states. The latter include type 1 and type …

BACKGROUND & AIMS: Vascular endothelial growth factor A (VEGF-A) mediates
angiogenesis and might also have a role in inflammation and immunity. We examined …

Cancer initiation and progression are multistep events that require cell proliferation,
migration, extravasation to the blood or lymphatic vessels, arrest to the metastatic site, and …

The placental growth factor (PlGF) is an angiogenic protein belonging to the vascular
endothelial growth factor (VEGF) family, which was discovered in 1991 by an Italian …

The oxygenation of polyunsaturated fatty acids such as arachidonic and linoleic acid
through lipoxygenases (LOX s) and cyclooxygenases (COX s) leads to the production of …

The selenoenzyme glutathione peroxidase 4 (GPx4) has been described to control specific
cyclooxygenases (COXs) and lipoxygenases (LOXs) that exert substantiated functions in …

Lipoxygenase-1 (15-LOX-1) is an inducible and highly regulated enzyme in normal human
cells that plays a key role in the production of lipid signaling mediators, such as 13 …

Inflammation and angiogenesis are intimately linked, and their dysregulation leads to
pathological angiogenesis in human diseases. 15-lipoxygenase (15-LOX) and lipoxin A4 …

Increasing uterine artery blood flow (UABF) may benefit fetal growth restriction where
impaired uteroplacental perfusion prevails. Based on previous short-term results, we …