Mechanical forces shape cells and tissues during development and adult homeostasis. In
addition, they also signal to cells via mechanotransduction pathways to control cell …

Herein, we review the multifaceted roles of proline in cell biology. This peculiar cyclic imino
acid is:(i) A main precursor of extracellular collagens (the most abundant human proteins) …

Cancer-associated fibroblasts (CAFs) are abundant stromal cells in the tumor
microenvironment that promote cancer progression and relapse. However, the …

Elevated production of collagen-rich extracellular matrix is a hallmark of cancer-associated
fibroblasts (CAFs) and a central driver of cancer aggressiveness. Here we find that proline, a …

Tumor cells evolve in a complex and heterogeneous environment composed of different cell
types and an extracellular matrix. Current 2D culture methods are very limited in their ability …

In recent years, in-depth studies have shown that extracellular matrix stiffness plays an
important role in cell growth, proliferation, migration, immunity, malignant transformation …

The metabolism of the non-essential amino acid L-proline is emerging as a key pathway in
the metabolic rewiring that sustains cancer cells proliferation, survival and metastatic …

Cancer cells often change their metabolism to support uncontrolled proliferation. Proline is
the only proteogenic secondary amino acid that is abundant in the body. Recent studies …

Cancer cells show a formidable capacity to survive under stringent conditions, to elude
mechanisms of control, such as apoptosis, and to resist therapy. Cancer cells reprogram …

The extracellular matrix (ECM) provides structural support and imparts a wide variety of
environmental cues to cells. In the past decade, a growing body of work revealed that the …