As an evolutionarily conserved signalling network, the Hippo pathway plays a crucial role in
the regulation of numerous biological processes. Thus, substantial efforts have been made …

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator
of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous …

Ferroptosis is a lipid peroxidation-dependent cell death caused by metabolic dysfunction.
Ferroptosis-associated enzymes are promising therapeutic targets for cancer treatment …

Two decades of studies in multiple model organisms have established the Hippo pathway
as a key regulator of organ size and tissue homeostasis. By inhibiting YAP and TAZ …

Lung cancer causes the largest number of cancer-related deaths in the world. Most (85%) of
lung cancers are classified as non-small-cell lung cancer (NSCLC) and small-cell lung …

Inflammation, epithelial cell regeneration, macrophage polarization, and gut microbial
homeostasis are critical for the pathological processes associated with inflammatory bowel …

Lung squamous cell carcinoma (LSCC) pathogenesis remains incompletely understood,
and biomarkers predicting treatment response remain lacking. Here, we describe novel …

Summary KRAS G12C inhibitors (adagrasib and sotorasib) have shown clinical promise in
targeting KRAS G12C-mutated lung cancers; however, most patients eventually develop …

A complex disease generally results not from malfunction of individual molecules but from
dysfunction of the relevant system or network, which dynamically changes with time and …

The Hippo pathway is a central regulator of organ size and tissue homeostasis. Hippo
kinases and adaptor proteins mediate the phosphorylation and inactivation of YAP and TAZ …