Biology and relevance of human acute myeloid leukemia stem cells
D Thomas, R Majeti - Blood, The Journal of the American …, 2017 - ashpublications.org
Evidence of human acute myeloid leukemia stem cells (AML LSCs) was first reported nearly
2 decades ago through the identification of rare subpopulations of engrafting cells in …
2 decades ago through the identification of rare subpopulations of engrafting cells in …
Tumour heterogeneity and cancer cell plasticity
CE Meacham, SJ Morrison - Nature, 2013 - nature.com
Phenotypic and functional heterogeneity arise among cancer cells within the same tumour
as a consequence of genetic change, environmental differences and reversible changes in …
as a consequence of genetic change, environmental differences and reversible changes in …
Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia
Acute myeloid leukemia (AML) is the most common acute leukemia in adults. Leukemia
stem cells (LSCs) drive the initiation and perpetuation of AML, are quantifiably associated …
stem cells (LSCs) drive the initiation and perpetuation of AML, are quantifiably associated …
The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells
Abstract N 6-methyladenosine (m6A) is an abundant nucleotide modification in mRNA that is
required for the differentiation of mouse embryonic stem cells. However, it remains unknown …
required for the differentiation of mouse embryonic stem cells. However, it remains unknown …
Inhibition of amino acid metabolism selectively targets human leukemia stem cells
In this study we interrogated the metabolome of human acute myeloid leukemia (AML) stem
cells to elucidate properties relevant to therapeutic intervention. We demonstrate that amino …
cells to elucidate properties relevant to therapeutic intervention. We demonstrate that amino …
Chemotherapy-resistant human acute myeloid leukemia cells are not enriched for leukemic stem cells but require oxidative metabolism
Chemotherapy-resistant human acute myeloid leukemia (AML) cells are thought to be
enriched in quiescent immature leukemic stem cells (LSC). To validate this hypothesis in …
enriched in quiescent immature leukemic stem cells (LSC). To validate this hypothesis in …
Targeting the RNA m6A reader YTHDF2 selectively compromises cancer stem cells in acute myeloid leukemia
Acute myeloid leukemia (AML) is an aggressive clonal disorder of hematopoietic stem cells
(HSCs) and primitive progenitors that blocks their myeloid differentiation, generating self …
(HSCs) and primitive progenitors that blocks their myeloid differentiation, generating self …
A 17-gene stemness score for rapid determination of risk in acute leukaemia
Refractoriness to induction chemotherapy and relapse after achievement of remission are
the main obstacles to cure in acute myeloid leukaemia (AML). After standard induction …
the main obstacles to cure in acute myeloid leukaemia (AML). After standard induction …
Leukemic stem cells evade chemotherapy by metabolic adaptation to an adipose tissue niche
Adipose tissue (AT) has previously been identified as an extra-medullary reservoir for
normal hematopoietic stem cells (HSCs) and may promote tumor development. Here, we …
normal hematopoietic stem cells (HSCs) and may promote tumor development. Here, we …
BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation
The branched-chain amino acid (BCAA) pathway and high levels of BCAA transaminase 1
(BCAT1) have recently been associated with aggressiveness in several cancer entities …
(BCAT1) have recently been associated with aggressiveness in several cancer entities …