Cells have the ability to respond to various types of environmental cues, and in many cases
these cues induce directed cell migration towards or away from these signals. How cells …

▪ Abstract Chemokines compose a sophisticated communication system used by all our cell
types, including immune cells. Chemokine messages are decoded by specific receptors that …

Langerhans cells (LCs) are bone marrow (BM)–derived epidermal dendritic cells (DCs) that
represent a critical immunologic barrier to the external environment, but little is known about …

The activity of the chemokine RANTES is not restricted merely to chemotaxis. It is a powerful
leukocyte activator, a feature potentially relevant in a range of inflammatory disorders …

Since their discovery 13 years ago, chemokines have emerged as the most important
regulators of leukocyte trafficking. On target cells, chemokines bind to seven-transmembrane …

Directed cell movement is integral to both embryogenesis and hematopoiesis. In the adult,
the chemokine family of secreted proteins signals migration of hematopoietic cells through G …

Cell migration plays a key role in a wide variety of biological phenomena. This process is
particularly important for leukocyte function and the inflammatory response. Prior to …

A broad array of biological responses, including cell polarization, movement, immune and
inflammatory responses, and prevention of HIV-1 infection, are triggered by the chemokines …

The cytoskeleton is a cellular network of structural, adaptor and signalling molecules that
regulates most cellular functions that are related to the immune response, including …

Although chemokines were originally defined as host defense proteins it is now clear that
their repertoire of functions extend well beyond this role. For example chemokines such as …