Developmental and epileptic encephalopathies, the most severe group of epilepsies, are
characterized by seizures and frequent epileptiform activity associated with developmental …

Generalized epilepsy affects 24 million people globally; at least 25% of cases remain
medically refractory. The thalamus, with widespread connections throughout the brain, plays …

Objective GNAO1‐related disorders (OMIM# 615473 and# 617493), caused by variants in
the GNAO1 gene, are characterized by developmental delay or intellectual disability …

Epilepsy affects 1% of the general population and 30% of patients are resistant to
antiepileptic drugs. Although optogenetics is an efficient antiepileptic strategy, the difficulty of …

Despite progress in the development of anti‐seizure medications (ASMs), one third of
people with epilepsy have drug‐resistant epilepsy (DRE). The working definition of DRE …

Seizures beget seizures is a longstanding theory that proposed that seizure activity can
impact the structural and functional properties of the brain circuits in ways that contribute to …

Although around 6% of the world's population is affected by rare diseases, only a small
number of disease‐modifying therapies are available. In recent years, antisense …

The past two decades have witnessed a wide range of studies investigating genetic variants
of voltage‐gated sodium (NaV) channels, which are involved in a broad spectrum of …

Hypersynchronous and exaggerated neuronal firing, exemplified by epileptiform activity and
seizures, are disruptors of brain function across acute and chronic neuropathological …

Precision medicine is an old concept, but it is not widely applied across human health
conditions as yet. Numerous attempts have been made to apply precision medicine in …