There has been a major emphasis on defining the role of seizures in the causation of
cognitive impairments like memory deficits in epilepsy. Here we focus on an alternative …

Temporal lobe epilepsy causes severe cognitive deficits, but the circuit mechanisms remain
unknown. Interneuron death and reorganization during epileptogenesis may disrupt the …

Spatial and non-spatial memories are key processes whereby we process our environment
on a daily basis, coding space, time and items to form unique memories. Both types of …

Impaired synaptic neurotransmission may underly circuit alterations contributing to
behavioral autism spectrum disorder (ASD) phenotypes. A critical component of impairments …

Core features of human cognition highlight the importance of the capacity to focus on
information distinct from events in the here and now, such as mind wandering. However, the …

Traumatic brain injury (TBI) is a leading cause of acquired epilepsy referred to as post-
traumatic epilepsy (PTE), characterized by spontaneous recurrent seizures (SRS) that start …

Hippocampal high-frequency electrographic activity (HFOs) represents one of the major
discoveries not only in epilepsy research but also in cognitive science over the past few …

Describing intracortical laminar organization of interictal epileptiform discharges (IED) and
high frequency oscillations (HFOs), also known as ripples. Defining the frequency limits of …

Seizures cause retrograde amnesia, but underlying mechanisms are poorly understood. We
tested whether seizure activated neuronal circuits overlap with spatial memory engram and …

Temporal lobe epilepsy (TLE) causes pervasive and progressive memory impairments, yet
the specific circuit changes that drive these deficits remain unclear. To investigate how …