The field of heart valve biomechanics is a rapidly expanding, highly clinically relevant area
of research. While most valvular pathologies are rooted in biomechanical changes, the …

The atrioventricular heart valves (AHVs) are responsible for directing unidirectional blood
flow through the heart by properly opening and closing the valve leaflets, which are …

Collagen fiber networks provide the structural strength of tissues, such as tendons, skin and
arteries. Quantifying the fiber architecture in response to mechanical loads is essential …

Current clinical assessment of functional tricuspid valve regurgitation relies on metrics
quantified from medical imaging modalities. Although these clinical methodologies are …

Mechanical characterization of the ex vivo tricuspid valve (TV) continues to provide key
insights into native valve function and the development of valvular diseases. However …

Background Three-dimensional speckle-tracking echocardiography (3DSTE) is a relatively
new non-invasive imaging modality with ability for simultaneous chamber quantifications …

Mechanical testing of soft tissues would ideally rely on using fresh specimens. In the event
that fresh tissues are not readily available, alternative measures, such as storing fresh …

There is a great demand for development of a functional tricuspid regurgitation (FTR) model
for accelerating development and preclinical study of tricuspid interventional repair devices …

Since many soft tissues function in an isotonic in-vivo environment, it is expected that
physiological osmolarity will be maintained when conducting experiments on these tissues …

Abstract Background and Aim: Ex vivo models of functional tricuspid regurgitation (FTR) are
needed for pre-clinical testing of novel surgical and interventional repair strategies, but …