Chromosome segregation in female germ cells and early embryonic blastomeres is known
to be highly prone to errors. The resulting aneuploidy is therefore the most frequent cause of …

The spindle assembly checkpoint (SAC) is a surveillance mechanism that prevents uneven
segregation of sister chromatids between daughter cells during anaphase. This essential …

Control mechanisms of spindle assembly and chromosome segregation are vital for
preventing aneuploidy during cell division. The mammalian germ cells and embryos are …

Preimplantation embryos often consist of a combination of euploid and aneuploid cells,
suggesting that safeguards preventing the generation and propagation of aneuploid cells in …

DNA damage during early life stages may have a negative effect on embryo development,
inducing mortality and malformations that have long-lasting effects during adult life …

Early embryogenesis is marked by a frail Spindle Assembly Checkpoint (SAC). The time of
SAC acquisition varies depending on the species, cell size or a yet to be uncovered …

Intercellular lumen formation is a crucial aspect of animal development and physiology that
involves a complex interplay between the molecular and physical properties of the …

The spindle assembly checkpoint (SAC) is a surveillance system that preserves genome
integrity by delaying anaphase onset until all chromosomes are correctly attached to spindle …

Spindle checkpoint strength is dictated by the number of unattached kinetochores, cell
volume, and cell fate. We show that the conserved AAA-ATPase PCH-2/TRIP13, which …

In recent years, pollution of surface waters with xenobiotic compounds became an issue of
concern in society and has been the object of numerous studies. Most of these xenobiotic …