Organelle transport is vital for the development and maintenance of axons, in which the
distances between sites of organelle biogenesis, function, and recycling or degradation can …

Synapses are highly specialized intercellular junctions that mediate the transmission of
information between axons and target cells. A fundamental property of synapses is their …

In a forward screen for genes affecting neurotransmission in Drosophila, we identified
mutations in dynamin-related protein (drp1). DRP1 is required for proper cellular distribution …

Abstract Griscelli syndrome (GS, MIM 214450), a rare, autosomal recessive disorder, results
in pigmentary dilution of the skin and the hair, the presence of large clumps of pigment in …

Synaptophysin (Syp) was the first synaptic vesicle (SV) protein to be cloned. Since its
discovery in 1985, it has been used by us and by many laboratories around the world as an …

In the past few years genetic, biochemical, and cytolocalization data have implicated
members of the myosin superfamily of actin-based molecular motors in a variety of cellular …

The mammalian central nervous system (CNS) requires the proper formation of exquisitely
precise circuits to function correctly. These neuronal circuits are assembled during …

▪ Abstract Cell polarity, as reflected by polarized growth and organelle segregation during
cell division in yeast, appears to follow a simple hierarchy. On the basis of physical cues …

Myosin V is an unconventional myosin proposed to be processive on actin filaments,
analogous to kinesin on a microtubule [Mehta, AD, et al.(1999) Nature (London) 400, 590 …

Myosin Va is a member of the unconventional class V myosin family, and a mutation in the
myosin Va gene causes pigment granule transport defects in human Griscelli syndrome and …