A copy number variation map of the human genome
A major contribution to the genome variability among individuals comes from deletions and
duplications—collectively termed copy number variations (CNVs)—which alter the diploid …
duplications—collectively termed copy number variations (CNVs)—which alter the diploid …
Expression, role, and regulation of neutrophil Fcγ receptors
Y Wang, F Jönsson - Frontiers in immunology, 2019 - frontiersin.org
Neutrophils are best known for their critical role in host defense, for which they utilize
multiple innate immune mechanisms, including microbe-associated pattern recognition …
multiple innate immune mechanisms, including microbe-associated pattern recognition …
Structural polymorphism and diversity of human segmental duplications
Segmental duplications (SDs) contribute significantly to human disease, evolution and
diversity but have been difficult to resolve at the sequence level. We present a population …
diversity but have been difficult to resolve at the sequence level. We present a population …
Malaria immunity in man and mosquito: insights into unsolved mysteries of a deadly infectious disease
PD Crompton, J Moebius, S Portugal… - Annual review of …, 2014 - annualreviews.org
Malaria is a mosquito-borne disease caused by parasites of the obligate intracellular
Apicomplexa phylum the most deadly of which, Plasmodium falciparum, prevails in Africa …
Apicomplexa phylum the most deadly of which, Plasmodium falciparum, prevails in Africa …
Fc receptor-targeted therapies for the treatment of inflammation, cancer and beyond
PM Hogarth, GA Pietersz - Nature reviews Drug discovery, 2012 - nature.com
The direct or indirect targeting of antibody Fc receptors (FcRs) presents unique opportunities
and interesting challenges for the treatment of inflammatory diseases, cancer and infection …
and interesting challenges for the treatment of inflammatory diseases, cancer and infection …
Autoimmunity and primary immunodeficiency: two sides of the same coin?
RE Schmidt, B Grimbacher, T Witte - Nature Reviews Rheumatology, 2018 - nature.com
Autoimmunity and immunodeficiency were previously considered to be mutually exclusive
conditions; however, increased understanding of the complex immune regulatory and …
conditions; however, increased understanding of the complex immune regulatory and …
IgG and Fcγ receptors in intestinal immunity and inflammation
T Castro-Dopico, MR Clatworthy - Frontiers in immunology, 2019 - frontiersin.org
Fcγ receptors (FcγR) are cell surface glycoproteins that mediate cellular effector functions of
immunoglobulin G (IgG) antibodies. Genetic variation in FcγR genes can influence …
immunoglobulin G (IgG) antibodies. Genetic variation in FcγR genes can influence …
A decade of structural variants: description, history and methods to detect structural variation
In the past decade, the view on genomic structural variation (SV) has been changed
completely. SVs, previously considered rare events, are now recognized as the largest …
completely. SVs, previously considered rare events, are now recognized as the largest …
Structural forms of the human amylase locus and their relationships to SNPs, haplotypes and obesity
Hundreds of genes reside in structurally complex, poorly understood regions of the human
genome,,. One such region contains the three amylase genes (AMY2B, AMY2A and AMY1) …
genome,,. One such region contains the three amylase genes (AMY2B, AMY2A and AMY1) …
Immunomodulation by IVIg and the role of Fc-gamma receptors: classic mechanisms of action after all?
SQ Nagelkerke, TW Kuijpers - Frontiers in immunology, 2015 - frontiersin.org
Intravenous IgG (IVIg) contains polyclonal immunoglobulin G (IgG) from thousands of
donors. It is administered at a low dose at regular intervals as antibody replacement therapy …
donors. It is administered at a low dose at regular intervals as antibody replacement therapy …