Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABA

PG Mullins, DJ McGonigle, RL O'Gorman, NAJ Puts… - Neuroimage, 2014 - Elsevier
There is increasing interest in the use of edited proton magnetic resonance spectroscopy for
the detection of GABA in the human brain. At a recent meeting held at Cardiff University, a …

Edited 1H magnetic resonance spectroscopy in vivo: Methods and metabolites

AD Harris, MG Saleh… - Magnetic resonance in …, 2017 - Wiley Online Library
The Proton magnetic resonance (1H‐MRS) spectrum contains information about the
concentration of tissue metabolites within a predefined region of interest (a voxel). The …

Preprocessing, analysis and quantification in single‐voxel magnetic resonance spectroscopy: experts' consensus recommendations

J Near, AD Harris, C Juchem, R Kreis… - NMR in …, 2021 - Wiley Online Library
Once an MRS dataset has been acquired, several important steps must be taken to obtain
the desired metabolite concentration measures. First, the data must be preprocessed to …

Reduced GABA and altered somatosensory function in children with autism spectrum disorder

NAJ Puts, EL Wodka, AD Harris, D Crocetti… - Autism …, 2017 - Wiley Online Library
Background: Abnormal responses to tactile stimuli are a common feature of autism spectrum
disorder (ASD). Several lines of evidence suggest that GABAergic function, which has a …

Gannet: A batch‐processing tool for the quantitative analysis of gamma‐aminobutyric acid–edited MR spectroscopy spectra

RAE Edden, NAJ Puts, AD Harris… - Journal of magnetic …, 2014 - Wiley Online Library
Purpose The purpose of this study is to describe the Gannet toolkit for the quantitative batch
analysis of gamma‐aminobutyric acid (GABA)‐edited MRS data. Materials and Methods …

Frequency and phase drift correction of magnetic resonance spectroscopy data by spectral registration in the time domain

J Near, R Edden, CJ Evans, R Paquin… - Magnetic resonance …, 2015 - Wiley Online Library
Purpose Frequency and phase drifts are a common problem in the acquisition of in vivo
magnetic resonance spectroscopy (MRS) data. If not accounted for, frequency and phase …

Spectral editing in 1H magnetic resonance spectroscopy: Experts' consensus recommendations

IY Choi, OC Andronesi, P Barker, W Bogner… - NMR in …, 2021 - Wiley Online Library
Spectral editing in in vivo 1H‐MRS provides an effective means to measure low‐
concentration metabolite signals that cannot be reliably measured by conventional MRS …

Reduced GABAergic inhibition and abnormal sensory symptoms in children with Tourette syndrome

NAJ Puts, AD Harris, D Crocetti… - Journal of …, 2015 - journals.physiology.org
Tourette Syndrome (TS) is characterized by the presence of chronic tics. Individuals with TS
often report difficulty with ignoring (habituating to) tactile sensations, and some patients …

Simultaneous edited MRS of GABA and glutathione

MG Saleh, G Oeltzschner, KL Chan, NAJ Puts… - Neuroimage, 2016 - Elsevier
Edited MRS allows the detection of low-concentration metabolites, whose signals are not
resolved in the MR spectrum. Tailored acquisitions can be designed to detect, for example …

Correcting frequency and phase offsets in MRS data using robust spectral registration

M Mikkelsen, S Tapper, J Near… - NMR in …, 2020 - Wiley Online Library
An algorithm for retrospective correction of frequency and phase offsets in MRS data is
presented. The algorithm, termed robust spectral registration (rSR), contains a set of …