The evolution of commercial drug delivery technologies

AM Vargason, AC Anselmo, S Mitragotri - Nature biomedical …, 2021 - nature.com
Drug delivery technologies have enabled the development of many pharmaceutical
products that improve patient health by enhancing the delivery of a therapeutic to its target …

[HTML][HTML] Oral delivery of therapeutic peptides and proteins: Technology landscape of lipid-based nanocarriers

S Haddadzadegan, F Dorkoosh… - Advanced drug delivery …, 2022 - Elsevier
The oral administration of therapeutic peptides and proteins is favoured from a patient and
commercial point of view. In order to reach the systemic circulation after oral administration …

Bioinspired adaptable indwelling microneedles for treatment of diabetic ulcers

X Zhang, J Gan, L Fan, Z Luo, Y Zhao - Advanced Materials, 2023 - Wiley Online Library
Microneedles provide an effective strategy for transdermal drug delivery. Many endeavors
have been devoted to develo** smart microneedles that can respond to and interact with …

Alzheimer's and Parkinson's disease therapies in the clinic

P Chopade, N Chopade, Z Zhao… - Bioengineering & …, 2023 - Wiley Online Library
Alzheimer's disease (AD) and Parkinson's disease (PD) are the most prevalent
neurodegenerative diseases, affecting millions and costing billions each year in the United …

Engineering microneedle patches for improved penetration: analysis, skin models and factors affecting needle insertion

P Makvandi, M Kirkby, ARJ Hutton, M Shabani… - Nano-Micro Letters, 2021 - Springer
Transdermal microneedle (MN) patches are a promising tool used to transport a wide variety
of active compounds into the skin. To serve as a substitute for common hypodermic needles …

Advances in oral peptide therapeutics

DJ Drucker - Nature reviews Drug discovery, 2020 - nature.com
Protein and peptide therapeutics require parenteral administration, which can be a deterrent
to medication adherence. For this reason, there have been extensive efforts to develop …

Peptide-based drug discovery: Current status and recent advances

K Sharma, KK Sharma, A Sharma, R Jain - Drug Discovery Today, 2023 - Elsevier
Highlights•A comprehensive compilation and analysis of FDA approved and under clinical
trials peptide-based therapeutics.•Clinical trial peptides pipeline analysis reveals emerging …

Hydrogel-based controlled drug delivery for cancer treatment: a review

Z Sun, C Song, C Wang, Y Hu, J Wu - Molecular pharmaceutics, 2019 - ACS Publications
As an emerging drug carrier, hydrogels have been widely used for tumor drug delivery. A
hydrogel drug carrier can cause less severe side effects than systemic chemotherapy and …

[HTML][HTML] Oral delivery of proteins and peptides: Challenges, status quo and future perspectives

Q Zhu, Z Chen, PK Paul, Y Lu, W Wu, J Qi - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules
than small molecular drugs due to their high selectivity and efficacy, but fewer side effects …

A mussel-inspired film for adhesion to wet buccal tissue and efficient buccal drug delivery

S Hu, X Pei, L Duan, Z Zhu, Y Liu, J Chen… - Nature …, 2021 - nature.com
Administration of drugs via the buccal route has attracted much attention in recent years.
However, develo** systems with satisfactory adhesion under wet conditions and …