Coenzyme Q biochemistry and biosynthesis

RM Guerra, DJ Pagliarini - Trends in biochemical sciences, 2023 - cell.com
Coenzyme Q (CoQ) is a remarkably hydrophobic, redox-active lipid that empowers diverse
cellular processes. Although most known for shuttling electrons between mitochondrial …

Biochemistry of mitochondrial coenzyme Q biosynthesis

JA Stefely, DJ Pagliarini - Trends in biochemical sciences, 2017 - cell.com
Coenzyme Q (CoQ, ubiquinone) is a redox-active lipid produced across all domains of life
that functions in electron transport and oxidative phosphorylation and whose deficiency …

The mitochondrial coenzyme Q junction and complex III: biochemistry and pathophysiology

R Banerjee, J Purhonen, J Kallijärvi - The FEBS journal, 2022 - Wiley Online Library
Coenzyme Q (CoQ, ubiquinone) is the electron‐carrying lipid in the mitochondrial electron
transport system (ETS). In mammals, it serves as the electron acceptor for nine mitochondrial …

Mitochondrial protein interaction map** identifies regulators of respiratory chain function

BJ Floyd, EM Wilkerson, MT Veling, CE Minogue, C **a… - Molecular cell, 2016 - cell.com
Mitochondria are essential for numerous cellular processes, yet hundreds of their proteins
lack robust functional annotation. To reveal functions for these proteins (termed MXPs), we …

Role of protein phosphorylation in cell signaling, disease, and the intervention therapy

K Pang, W Wang, JX Qin, ZD Shi, L Hao, YY Ma… - MedComm, 2022 - Wiley Online Library
Protein phosphorylation is an important post‐transcriptional modification involving an
extremely wide range of intracellular signaling transduction pathways, making it an …

Coenzyme Q10 deficiencies: pathways in yeast and humans

AM Awad, MC Bradley… - Essays in …, 2018 - portlandpress.com
Coenzyme Q (ubiquinone or CoQ) is an essential lipid that plays a role in mitochondrial
respiratory electron transport and serves as an important antioxidant. In human and yeast …

The classification of autosomal recessive cerebellar ataxias: a consensus statement from the society for research on the cerebellum and ataxias task force

M Beaudin, A Matilla-Dueñas, BW Soong, JL Pedroso… - The Cerebellum, 2019 - Springer
There is currently no accepted classification of autosomal recessive cerebellar ataxias, a
group of disorders characterized by important genetic heterogeneity and complex …

Understanding coenzyme Q

Y Wang, N Lilienfeldt, S Hekimi - Physiological Reviews, 2024 - journals.physiology.org
Coenzyme Q (CoQ), also known as ubiquinone, comprises a benzoquinone head group and
a long isoprenoid side chain. It is thus extremely hydrophobic and resides in membranes. It …

LipiDex: an integrated software package for high-confidence lipid identification

PD Hutchins, JD Russell, JJ Coon - Cell systems, 2018 - cell.com
State-of-the-art proteomics software routinely quantifies thousands of peptides per
experiment with minimal need for manual validation or processing of data. For the emerging …

Primary Coenzyme Q deficiencies: A literature review and online platform of clinical features to uncover genotype-phenotype correlations

M Alcázar-Fabra, F Rodríguez-Sánchez… - Free Radical Biology …, 2021 - Elsevier
Abstract Primary Coenzyme Q (CoQ) deficiencies are clinically heterogeneous conditions
and lack clear genotype-phenotype correlations, complicating diagnosis and prognostic …