In 2007 the members of the ACS Green Chemistry Institute® Pharmaceutical Roundtable
assembled a list of key green chemistry research areas to both identify transformations that …

The direct, catalytic dehydrative substitution of alcohols is a challenging, yet highly desirable
process in the development of more sustainable approaches to organic chemistry. This …

Nucleophilic substitution reactions of alcohols are among the most fundamental and
strategically important transformations in organic chemistry. For over half a century, these …

The introduction and precise control of stereogenic elements in chemical structures is
typically a challenging task. Most asymmetric methods require the presence of a heteroatom …

Nucleophilic substitutions (SN) account for the most essential and frequently applied
chemical transformations. SN‐reactions allow forging C–C, C–O, C–N and C–Cl bonds, for …

Abstract Chiral 1, n‐bis (boronate) plays a crucial role in organic synthesis and medicinal
chemistry. However, their catalytic and asymmetric synthesis has long posed a challenge in …

The catalytic deoxyamination of readily available 2‐arylethanols offers an appealing, simple,
and straightforward means of accessing β‐(hetero) arylethylamines of biological interest …

Optically pure alcohols are abundant in nature and attractive as feedstock for organic
synthesis but challenging for further transformation using atom efficient and sustainable …

A catalytic protocol for the iridium-catalyzed asymmetric hydrogenation (AH) of γ-or δ-
hydroxy ketones to rapidly assemble various aliphatic enantioenriched tetrahydrofurans …

A catalytic and versatile synthetic method for the synthesis of imidazo [1, 2-a] pyridines has
been developed. Brønsted acid-catalysis plays a major role in the regioselective ring …