The gut microbiome exerts a considerable influence on human neurophysiology and mental
health. Interactions between intestinal microbiology and host regulatory systems have now …

Introduction As individuals age, the prevalence of neurocognitive and mental health
disorders increases. Current biomedical treatments do not completely address the …

The human gut contains trillions of symbiotic bacteria that play a key role in programming
different aspects of host physiology in health and disease. Psychotropic medications act on …

Schizophrenia is a heterogeneous neurodevelopmental disorder involving the convergence
of a complex and dynamic bidirectional interaction of genetic expression and the …

Increasing evidence shows changes in gut microbiota composition in association with
psychiatric disorders, including anxiety and depression. Moreover, it has been reported that …

Infections are a growing global threat, and the number of resistant species of microbial
pathogens is alarming. However, the rapid development of cross-resistant or multidrug …

Rationale Multiple drugs are known to induce metabolic malfunctions, among them second-
generation antipsychotics (SGAs). The pathogenesis of such adverse effects is of …

The heterogeneous class of what we nowadays call antipsychotics was born almost 70
years ago with the serendipitous discovery of chlorpromazine. Their utilization is constantly …

Efflux is an important mechanism in Gram-negative bacteria conferring multidrug resistance.
Inhibition of efflux is an encouraging strategy to restore the antibacterial activity of antibiotics …

The global spread of microbial resistance coupled with high costs and slow pace in the
discovery of a new antibiotic have made drug repositioning an attractive and promising …