Oral submucous fibrosis: etiological mechanism, malignant transformation, therapeutic approaches and targets

X Qin, Y Ning, L Zhou, Y Zhu - International journal of molecular sciences, 2023 - mdpi.com
Oral submucosal fibrosis (OSF) is a chronic, progressive and potentially malignant oral
disorder with a high regional incidence and malignant rate. With the development of the …

MicroRNAs as modulators of oral tumorigenesis—A focused review

K Rishabh, S Khadilkar, A Kumar, I Kalra… - International journal of …, 2021 - mdpi.com
Oral cancers constitute the majority of head and neck tumors, with a relatively high incidence
and poor survival rate in develo** countries. While the five-year survival rates of the oral …

Analysis of oral lichen planus severity on micro‐RNA linked with malignant transformation risks

A Polizzi, S Santonocito, A Distefano… - Oral …, 2024 - Wiley Online Library
Objective The present study evaluated the oral tissue expression of micro‐RNA (miRNAs)
linked to the potential malignant evolution of oral lichen planus (OLP). Furthermore, the …

miRNAs as biomarkers for diagnosing and predicting survival of head and neck squamous cell carcinoma patients

I Piotrowski, X Zhu, TD Saccon, S Ashiqueali… - Cancers, 2021 - mdpi.com
Simple Summary Head and Neck Squamous Cell Carcinoma (HNSCC) is the sixth most
common cancer worldwide. It arises from the epithelium of the upper aerodigestive tract …

Natural compounds targeting miRNAs: a novel approach in oral cancer therapy

YA Doghish, AS Doghish, SSA Mageed… - Functional & Integrative …, 2024 - Springer
Oral cancer (OC) is a significant global health issue, with high rates of both mortality and
morbidity. Conventional treatments, including surgery, radiation, and chemotherapy, are …

Non-coding RNAs in oral cancer: emerging roles and clinical applications

S Dey, B Biswas, A Manoj Appadan, J Shah, JK Pal… - Cancers, 2023 - mdpi.com
Simple Summary Oral cancer (OC) is one of the most prevalent cancers in the world. Despite
improvements in therapies, OC still has a poor survival rate of about 50%, with metastasis …

Head and neck cancers are not alike when tarred with the same brush: An epigenetic perspective from the cancerization field to prognosis

D Camuzi, TA Simão, F Dias, LF Ribeiro Pinto… - Cancers, 2021 - mdpi.com
Simple Summary Squamous cell carcinomas affect different head and neck subsites and,
although these tumors arise from the same epithelial lining and share risk factors, they differ …

[HTML][HTML] miR-1293, a candidate for miRNA-based cancer therapeutics, simultaneously targets BRD4 and the DNA repair pathway

Y Takagawa, Y Gen, T Muramatsu, K Tanimoto… - Molecular Therapy, 2020 - cell.com
BRD4, a member of the bromodomain and extra-terminal domain (BET) protein family, plays
a role in the organization of super-enhancers and transcriptional activation of oncogenes in …

Nanoparticulate strategies for the delivery of miRNA mimics and inhibitors in anticancer therapy and its potential utility in oral submucous fibrosis

J Manikkath, PV Jishnu, PR Wich, A Manikkath… - …, 2022 - Taylor & Francis
MicroRNAs (miRNAs) are naturally occurring noncoding RNAs with multiple functionalities.
They are dysregulated in several conditions and can serve as disease biomarkers …

Assessing miRNAs profile expression as a risk stratification biomarker in oral potentially malignant disorders: A systematic review

H El-Sakka, O Kujan, CS Farah - Oral oncology, 2018 - Elsevier
Objectives This paper aims to systematically review current findings on altered expression of
miRNAs in OPMDs and whether they can be used as risk stratification biomarkers. Methods …