Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …

The immune system is highly time-of-day dependent. Pioneering studies in the 1960s were
the first to identify immune responses to be under a circadian control. Only in the last …

Rheumatoid arthritis (RA) is characterized by systemic synovitis leading to joint destruction
in which imbalances in pro-inflammatory and anti-inflammatory cytokines promote the …

Metformin is one of the most widely prescribed hypoglycemic drugs and has the potential to
treat many diseases. More and more evidence shows that metformin can regulate the …

In the panorama of inflammatory arthritis, gout is the most common and studied disease. It is
known that hyperuricemia and monosodium urate (MSU) crystal-induced inflammation …

REV-ERB nuclear receptors are potent transcriptional repressors that play an important role
in the core mammalian molecular clock and metabolism. Deletion of both REV-ERBα and its …

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by multi-articular,
symmetrical and invasive arthritis resulting from immune system abnormalities involving T …

Circadian rhythms exert a profound impact on most aspects of mammalian physiology,
including the immune and cardiovascular systems. Leukocytes engage in time-of-day …

Patients admitted to the intensive care unit (ICU) are in need of continuous organ
replacement strategies and specialized care, for example because of neurological …

Chronic sterile inflammation and persistent immune activation is a prominent pathological
feature of Parkinson's disease (PD). Inflammasomes are multi-protein intracellular signaling …