Functional aging in male C57BL/6J mice across the life-span: a systematic behavioral analysis of motor, emotional, and memory function to define an aging phenotype

S Yanai, S Endo - Frontiers in aging neuroscience, 2021 - frontiersin.org
Aging is characterized generally by progressive and overall physiological decline of
functions and is observed in all animals. A long line of evidence has established the …

Brief, daily meditation enhances attention, memory, mood, and emotional regulation in non-experienced meditators

JC Basso, A McHale, V Ende, DJ Oberlin… - Behavioural brain …, 2019 - Elsevier
Meditation is an ancient practice that cultivates a calm yet focused mind; however, little is
known about how short, practical meditation practices affect cognitive functioning in …

The evolution of preclinical Alzheimer's disease: implications for prevention trials

R Sperling, E Mormino, K Johnson - Neuron, 2014 - cell.com
As the field begins to test the concept of a" preclinical" stage of neurodegenerative disease,
when the pathophysiological process has begun in the brain, but clinical symptoms are not …

Regulation and function of adult neurogenesis: from genes to cognition

JB Aimone, Y Li, SW Lee… - Physiological …, 2014 - journals.physiology.org
Adult neurogenesis in the hippocampus is a notable process due not only to its uniqueness
and potential impact on cognition but also to its localized vertical integration of different …

Vascular hippocampal plasticity after aerobic exercise in older adults

A Maaß, S Düzel, M Goerke, A Becke, U Sobieray… - Molecular …, 2015 - nature.com
Aerobic exercise in young adults can induce vascular plasticity in the hippocampus, a critical
region for recall and recognition memory. In a mechanistic proof-of-concept intervention over …

Integrating new findings and examining clinical applications of pattern separation

SL Leal, MA Yassa - Nature neuroscience, 2018 - nature.com
Pattern separation, the ability to independently represent and store similar experiences, is a
crucial facet of episodic memory. Growing evidence suggests that the hippocampus …

Hippocampal neurogenesis: learning to remember

O Lazarov, C Hollands - Progress in neurobiology, 2016 - Elsevier
Alzheimer's disease, the most prevalent form of dementia in the elderly, is characterized by
progressive memory loss and cognitive dysfunction. It has become increasingly clear that …

[HTML][HTML] Response of the medial temporal lobe network in amnestic mild cognitive impairment to therapeutic intervention assessed by fMRI and memory task …

A Bakker, MS Albert, G Krauss, CL Speck… - NeuroImage: Clinical, 2015 - Elsevier
Studies of individuals with amnestic mild cognitive impairment (aMCI) have detected
hyperactivity in the hippocampus during task-related functional magnetic resonance imaging …